STUDIES ON A NEW 1, 5-BENZOTHIAZEPINE DERIVATIVE (CRD-401) : II. VASODILATOR ACTIONS
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概要
- 論文の詳細を見る
In a previous report (1), it was shown that a new 1, 5-benzothiazepine derivative, 3-acetoxy-2, 3-dihydro-5-[2-(diethylamino) ethyl]-2-(p-methoxyphenyl)-1, 5-benzothiazepine-4 (5H)-one hydrochloride, produced a potent coronary vasodilator effect in anesthetized dogs. Among four stereoisomers of the compound, <I>d</I>- and <I>l</I>-isomers of cis- and transforms, the <I>d</I>-cis-isomer (CRD-401) exhibited the most powerful effect when injected into the femoral vein. Without increase in myocardial oxygen consumption, a significant increase in coronary blood flow resulted.<BR> The present report deals with the vasodilator action of <I>d</I>-cis-isomer of the new benzothiazepine derivative under the influence of various pharmacological blockers. The results are considered in relation to the mechanism of the compound. Effects of <I>dl</I>- and <I>l</I>-cis-isomers and <I>dl</I>-trans-isomer were also investigated and compared with the action of <I>d</I>-cis-isomer. Experiments were performed on the coronary and femoral arteries in anesthetized dogs and on the coronary vessels in isolated hearts of the guinea pig.
- 社団法人 日本薬理学会の論文
著者
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Sato Masanori
Biology Division, National Cancer Center Research Institute
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Nagao Taku
Biological Research Laboratory Tanabe Seiyaku Co. Ltd.
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Nakajima Hiromichi
Biological Research Laboratory Tanabe Seiyaku Co. Ltd.
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KIYOMOTO Akio
Biological Research Laboratory, Tanabe Seiyaku Co., Ltd.
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SATO Masanori
Biological and Chemical Reseach Labolatories, Tanabe Seiyaka Co., Ltd.
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NAKAJIMA Hiromichi
Biological and Chemical Reseach Labolatories, Tanabe Seiyaka Co., Ltd.
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NAGAO Taku
Biological Research Laboratories, Tauabe Seiyaku Co., Ltd.
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KIYOMOTO Akio
Biological and Chemical Reseach Labolatories, Tanabe Seiyaka Co., Ltd.
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