STUDIES ON HORMONAL ACTIONS OF DIHYDROXYPROGESTERONE ACETOPHENIDE, ESTRADIOL ENANTHATE AND THEIR MIXURES

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Recent global trends of population increase has turned attention to hormonal control of ovulation as an effective contraceptive. Consequently, oral contraceptives have been studied and are generally utilized in the North America and Europe. These are used in a combination of progestogens and estrogens, in either a combination or sequential method. A near perfect contraceptive result is effected, however, carelessness or misuse often results in failure (1).<BR> It has been reported that acetophenone derivatives of 16α, 17α-dihydroxyprogesterone show long-lasting potent progestational activity (2-4). In view of this, attempts have been made to produce a contraceptive effect via a monthly intramuscular injection of the steroid which has been dissolved in vegetable oil. In this administration a certain prolonged concentration of the steroid is maintained in the blood, subsequently, the question is raised as to endocrinological side effects of the steroid or toxicities. The objective of the present work is to determine in rats, hormonal action of a mixture of dihydroxyprogesterone acetophenide and estradiol enanthate, one of the test preparations of parental contraceptive, developed by Squibb Institute for Medical Research.
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