ELECTROSHOCK, LIVER SEROTONIN LEVEL AND TRYPTOPHAN PYRROLASE ACTIVITY IN RATS

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概要

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• The preceding paper (1) revealed that electroshock induced the elevation of blood serotonin level which caused the changes of carbohydrate metabolism, i.e., hypoglycemia, hyperlactacidemia, decrease of liver glycogen and disappearance of initial peak in glucose tolerance test in rats. Recent investigation by Frieden <I>et al</I>. (2) has indicated the inhibition of tryptophan pyrrolase (TPO) activity by serotonin and indole derivatives <I>in vitro</I>. In the present study we have therefore investigated the changes of both liver serotonin level induced by electroshock or administration of monoamine oxidase inhibitor (MAOI) and TPO activity.

• 社団法人 日本薬理学会の論文

著者

• 佐藤 哲男

  Department of Pharmacology and Toxicology, Institute of Food Microbiology, Chiba University

• 岩本 多喜男

  Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Hokkaido University

関連論文

• Inhibition of Tryptophan Pyrrolase of Rats by Phenols, Tryptophan Analogs and Hydrazine Derivatives
• EFFECT OF SEX HORMONES ON THE THIORIDAZINE-INDUCED INHIBITION OF CONDITIONED AVOIDANCE RESPONSE IN THE RAT
• EFFECTS OF THIAMINE PROPYL DISULFIDE ON TRYPTOPHAN PYRROLASE IN RATS
• ELECTROSHOCK, LIVER SEROTONIN LEVEL AND TRYPTOPHAN PYRROLASE ACTIVITY IN RATS
• DEVELOPMENT OF TOLERANCE TO CHLORPROMAZINE IN THE RAT
• GLYCEMIC EFFECTS OF SOLANINE IN RATS
• DEVELOPMENT OF TOLERANCE TO TRANQUILLIZERS IN THE RAT

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