DEVELOPMENT OF TOLERANCE TO TRANQUILLIZERS IN THE RAT

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概要

• 論文の詳細を見る

• It is a well-known fact that the repeated administration of psychotropic drugs often leads to the development of tolerance in animals. As to tranquillizers, it has been reported by some investigators that the tolerance phenomenon was observed in rats or cats following the chronic treatment with chlorpromazine (1) and meprobamate (2, 3). The present paper deals with the effect of some tranquillizers on the conditioned avoidance response observed with the use of the Miller-Mowrer-type apparatus as well as the development of tolerance to these drugs in the rat.

• 公益社団法人 日本薬理学会の論文

著者

• 岩本 多喜男

  Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Hokkaido University

• 松木 勝彦

  Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Hokkaido University

関連論文

• EFFECT OF SEX HORMONES ON THE THIORIDAZINE-INDUCED INHIBITION OF CONDITIONED AVOIDANCE RESPONSE IN THE RAT
• ELECTROSHOCK, LIVER SEROTONIN LEVEL AND TRYPTOPHAN PYRROLASE ACTIVITY IN RATS
• DEVELOPMENT OF TOLERANCE TO CHLORPROMAZINE IN THE RAT
• DEVELOPMENT OF TOLERANCE TO TRANQUILLIZERS IN THE RAT

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