THE CONTENTS OF DOPA AND CATECHOLAMINES IN SEVERAL RAT TISSUES AND NICOTINE-INDUCED CONVULSIONS

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概要

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• Referring to the relationship between the pharmacological actions of nicotine and the biogenic active substances, a certain biogenic amine released by nicotine has been suggested to participate in some pharmacological actions of nicotine (1). Especially the release of epinephrine from the adrenal medulla by nicotine has been proven (2-7). The significance of the actions of biogenic amines has been recognized to elucidate the mechanism of the drug actions, since much more reliable methods of assays for identification were developed (8-13).<BR> The present experiment was designed to observe the relationship between the contents of the biogenic catechols in the several tissues of rats and the behavial changes of three patterns of nicotine-induced convulsions.

• 公益社団法人 日本薬理学会の論文

著者

• 山本 巌

  Department of Pharmacology, Osaka University Dental School

• 猪木 令三

  Department of Pharmacology, Osaka University Dental School

• 永井 和男

  Department of Neuropharmacology and Neurochemistry, Institute for Higher Nervous Activity, Osaka University

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• INHIBITORY EFFECT OF 8-AZAGUANINE ON THE DEVELOPMENT OF TOLERANCE IN THE ANALGESIC ACTION OF MORPHINE
• ACCUMULATION OF 14C-NICOTINE IN MOUSE BRAIN AFTER THE INTRAPERITONEAL INJECTION
• ANTAGONISTIC EFFECT OF PHENOTHIAZINE DERIVATIVES ON NICOTINE-INDUCED DEATH IN MICE
• NICOTINE AND SOME CARCINOGENS IN SPECIAL REFERENCE TO THE HEPATIC DRUG-METABOLIZING ENZYMES
• GANGLION BLOCKING PROPERTIES OF THIAMINE AND ITS RELATED COMPOUNDS
• THIAMINE AS A NICOTINE ANTAGONIST
• THE CONTENTS OF DOPA AND CATECHOLAMINES IN SEVERAL RAT TISSUES AND NICOTINE-INDUCED CONVULSIONS
• PHARMACOLOGICAL STUDIES ON ANTAGONISTS AGAINST NICOTINE-INDUCED CONVULSIONS AND DEATH

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