GANGLION BLOCKING PROPERTIES OF THIAMINE AND ITS RELATED COMPOUNDS

概要

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In the course of investigation of antagonistic actions of thiamine against nicotine, Yamamoto and his co-workers led to a conclusion that a main antagonistic site in the peripheral region is the nervous ganglion and the antagonistic action is involved in the competition at the receptor site (1-6). The antagonism between nicotine and thiamine dealt with the investigation was by no means referable to the action of thiamine as a vitamin. In its thiazole ring structure thiamine has a quaternary ammonium, as other ganglion blockers have. The ganglion blocking action of thiamine on the cat's nictitating membrane has been previously demonstrated by Yamamoto and his co-workers (3-6) and Mazzella <I>et al</I>. (7). The present investigation was undertaken to compare the pharmacological properties of thiamine and its related compounds with those of hexamethonium and tetraethylammonium with special reference to the ganglion blocking activity.
公益社団法人日本薬理学会の論文