THIAMINE AS A NICOTINE ANTAGONIST

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概要

• 論文の詳細を見る

• Serial studies have been brought about on the nicotine detoxication with special reference to the metabolic fate of nicotine (1-7) and also on the action mechanism of nicotine antagonists (8-12) by Yamamoto and his coworkers since 1951. The fact that thiamine possessed an antagonistic action on nicotine toxicity was firstly pointed out by Unna <I>et al</I>. in 1944 (13) and the present author found also that thiamine inhibited selectively the action of nicotine as well as nornicotine <I>in vitro</I>.<BR> The present experiment was aimed to elucidate the antagonistic mechanism between thiamine and nicotine, and also to investigate the structure-activity relationship of various thiamine related compounds.

• 公益社団法人 日本薬理学会の論文

著者

• 山本 巌

  Department of Pharmacology, Osaka University Dental School

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• ACCUMULATION OF 14C-NICOTINE IN MOUSE BRAIN AFTER THE INTRAPERITONEAL INJECTION
• ANTAGONISTIC EFFECT OF PHENOTHIAZINE DERIVATIVES ON NICOTINE-INDUCED DEATH IN MICE
• NICOTINE AND SOME CARCINOGENS IN SPECIAL REFERENCE TO THE HEPATIC DRUG-METABOLIZING ENZYMES
• GANGLION BLOCKING PROPERTIES OF THIAMINE AND ITS RELATED COMPOUNDS
• THIAMINE AS A NICOTINE ANTAGONIST
• THE CONTENTS OF DOPA AND CATECHOLAMINES IN SEVERAL RAT TISSUES AND NICOTINE-INDUCED CONVULSIONS
• PHARMACOLOGICAL STUDIES ON ANTAGONISTS AGAINST NICOTINE-INDUCED CONVULSIONS AND DEATH

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