THE ELECTRONIC STRUCTURE OF CARBAMATE DERIVATIVES AS THE INHIBITORS OF CHOLINESTERASE

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概要

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• The inhibition of cholinesterase by some of carbamates has attracted the attention of many researchers in relation to the clinical usefulness (1) and insecticidal activity (2, 3) of the compounds.<BR> In this paper the author's chief concern is mainly devoted to investigating the relationship between the electronic structure of several structurally related carbamate type cholinesterase inhibitors and the inhibitory potency of these compounds against true (acetyl) cholinesterase, on the basis of the experiments of Kolbezen <I>et al</I>. (2), Myers <I>et al</I>. (4) and Wilson <I>et al</I>. (5) and to trying to analyse the inhibitory mechanism of them by this means.

• 公益社団法人 日本薬理学会の論文

著者

• 永田 親義

  National Cancer Center Research Institute

• 伴 隆志

  Department of Pharmacology, Faculty of Medicine, Kyoto University

• 永田 親義

  National Cancer Research Institute

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• THE ELECTRONIC STRUCTURE OF CARBAMATE DERIVATIVES AS THE INHIBITORS OF CHOLINESTERASE

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