STUDIES ON SULFHEMOGLOBIN FORMATION BY VARIOUS DRUGS (5) THE MECHANISM OF SULFHEMOGLOBIN FORMATION AND SPECIES DIFFERENCES IN METHEMOGLOBIN AND SULFHEMOGLOBIN FORMATION
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概要
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The mechanism of sulfhemoglobin (SHb) formation and species differences in the formation of SHb and methemoglobin (MHb) were investigated. Erythrocytes or hemolysates were incubated with phenylhydroxylamine (PHA), aniline or its monochloro derivatives in the presence or absence of liver microsomes from various species (mouse, rat, guinea pig, rabbit, cat, dog and monkey). It was confirmed that SHb was produced by the N-hydroxy metabolites of aniline and its derivatives and was not induced <I>via</I> MHb. There was a relationship in SHb or MHb formation between the chemical structure of aniline derivatives and their N-hydroxy metabolite production activities in the animals (<I>in vivo</I> and <I>in vitro</I>). Species differences in the production rates of N-hydroxy metabolites from aniline and its derivatives by liver microsomes (as well as in the susceptibility of erythrocytes to N-hydroxy compounds) <I>in vitro</I> were not reflected in species differences in MHb and SHb formation <I>in vivo</I>.
- 社団法人 日本薬理学会の論文
著者
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Nomura Akira
Department Of Biochemistry Kyorin University School Of Medicine
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Fujimura Hajime
Department Of Pharmacology Gifu University School Of Medicine
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Nomura Akira
Department Of Analytical Chemistry National Institute Of Materials And Chemical Research
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NOMURA Akira
Department of Pharmacology, Gifu University School of Medicine
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FUJIMURA Hajime
Department of Internal Medicine and Pharmacology, Gifu University School of Medicine
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