INFLUENCE OF SOME ANTI-INFLAMMATORY, ANTIPYRETIC AND ANALGESIC AGENTS ON URINARY ENZYME LEVEL IN RATS
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概要
- 論文の詳細を見る
The influence of single oral dose of anti-inflammatory, antipyretic and analgesic agents on urinary enzymes was investigated in rats as a indicator of nephrotoxic effect. Urinary LDH activity was significantly elevated by aspirin, ketophenylbutazone, aminopyrine, phenacetin and acetaminophen. These drugs increased also H/M ratio of LDH isoenzymes. Although other test drugs have no effect on LDH in urine phenylbutazone and indomethacin elevated GPT and Al-P, oxyphenbutazone did γ-GT and anthranilic acid derivatives did Al-P and γ-GT. Other drugs such as sodium salicylate, ibufenac, ibuprofen, bucolome, aminopropylone, sulfinpyrazone, benzydamine and mepirizole did not significantly influence any enzyme activities measured in urine.
- 日本トキシコロジー学会の論文
- 1978-02-15
著者
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ABE Akira
Department of Internal Medicine, Nephrology Division, University of Michigan
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Tsurumi Kaito
Department Of Pharmacology Gifu University School Of Medicine
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Fujimura Hajime
Department Of Pharmacology Gifu University School Of Medicine
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NOZAKI MASAKATSU
岐阜大学医学部
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Nozaki Masakatsu
Department Of Pharmacology Gifu University School Of Medicine
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Abe Akira
Department Of Internal Medicine Nephrology Division University Of Michigan
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Abe Akira
Department Of Pharmacology Gifu University School Of Medicine
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Fujimura Hajime
Dept. Of Pharmacology Gifu University School Of Medicine
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FUJIMURA Hajime
Department of Internal Medicine and Pharmacology, Gifu University School of Medicine
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Abe Akira
Department of Cardiology, Niigata Minami Hospital, Japan
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