SITE OF THE GANGLION BLOCKING ACTION OF GARDNERAMINE AND HIRSUTINE IN THE DOG URINARY BLADDER IN SITU PREPARATION
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概要
- 論文の詳細を見る
The ganglion blocking site of gardneramine (GA) and hirsutine (HS) was studied in the dog urinary bladder in an in situ preparation. GA and HS selectively inhibited the DMPP-induced contraction without having an antagonistic effect on the McN-A-343-induced and acetylcholine-induced contraction. In addition, since GA and HS showed a local anesthetic action weaker than that of procaine, the effect of procaine was studied on the same preparation. Procaine inhibited the McN-A-343-induced contraction, and it slightly inhibited the DMPP-induced and acetylcholine-induced contraction. From these findings, it is concluded that GA and HS inhibited the ganglionic transmission of the dog urinary bladder and that the blockade of the nicotinic receptor played a main role.
- 社団法人 日本薬理学会の論文
著者
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Ozaki Yukihiro
Department Of Chemistry And Research Center For Near-infrared Spectroscopy School Of Science And Tec
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Harada Masatoshi
Department Of Drug Evaluation And Toxicological Sciences Faculty Of Pharmaceutical Sciences Chiba Un
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OZAKI Yukihiro
Department of Drug Evaluation and Toxicological Sciences, Faculty of Pharmaceutical Sciences, Chiba University
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