STRESS PROCEDURES LOWERING BODY TEMPERATURE AUGMENT GASTRIC MOTILITY BY INCREASING THE SENSITIVITY TO ACETYLCHOLINE IN RATS
スポンサーリンク
概要
- 論文の詳細を見る
Exposure of rats to restraint plus water-immersion (25℃) stress produces a marked increase in gastric motility with hypothermia. Although this phenomenon was generally considered to be due to centrally mediated cholinergic mechanisms, the present study was designed to elucidate some local peripheral mechanism in enhancing gastric motility with hypothermia. After the onset of water-immersion (37-17℃), body temperature rapidly varied depending on water temperature and gastric motility changed in its pattern with stress duration ; increase in gastric motility reached a maximum at 25℃ but declined at 17℃. These alterations of gastric motility pattern were not primarily associated with activation or decline of the sympatho-aderenal system. In these stressed rats, either vagally intact or vagotomized, contractile responses of the stomach to i.v. or i.a. administration of bethanechol and acetylcholine, but not to that of histamine, were markedly augmented by lowering body temperature. Similar observations were noted in rats exposed to restraint plus cold (6℃) stress. These results emphasize the possibility that augmentation of gastric motility during waterimmersion (25℃) occurs at least in part through local peripheral mechanisms of increasing the contractile sensitivity of the stomach to acetylcholine with hypothermia.
- 公益社団法人日本薬学会の論文
著者
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Shibata Masahiro
Department Of Biomedical Engineering University Of Tokyo
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Yano Shingo
Department Of Molecular Pharmacology And Pharmacotherapeutics Graduate School Of Pharmaceutical Scie
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Harada Masatoshi
Department Of Drug Evaluation And Toxicological Sciences Faculty Of Pharmaceutical Sciences Chiba Un
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Harada Masatoshi
Department Of Drug Evaluation And Toxicological Sciences Faculty Of Pharmaceutical Sciences Chiba Un
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Shibata Masahiro
Department Of Drug Evaluation And Toxicological Sciences Faculty Of Pharmaceutical Sciences Chiba Un
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MATSUKURA HITOSHI
Department of Drug Evaluation and Toxicological Sciences, Faculty of Pharmaceutical Sciences, Chiba
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Yano Shingo
Department Of Drug Evaluation And Toxicological Sciences Faculty Of Pharmaceutical Sciences Chiba Un
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Yano Shingo
Department Of Drug Evaluation And Toxicological Sciences Faculty Of Pharmaceutical Sciences Chiba Un
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Matsukura Hitoshi
Department Of Drug Evaluation And Toxicological Sciences Faculty Of Pharmaceutical Sciences Chiba Un
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Shibata Masahiro
Department Of Applied Biology Faculty Of Textile Science Kyoto Institute Of Technology
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