Inhibitory actions of vecuronium bromide on acetylcholine and glutamate responses at the frog and crayfish neuromuscular junction.

スポンサーリンク

概要

• 論文の詳細を見る

• Effects of vecuronium bromide, an analog of pancuronium, on the cholinergic and glutamatergic neuromuscular junction were investigated. Vecuronium depressed the postsynaptic response of the frog end-plate at lower concentrations than 10<SUP>-6</SUP> g/ml without affecting the presynaptic events. Vecuronium decreased the amplitude of the double ACh potential, but the second potential was more markedly reduced than the first. In analogy with d-tubocurarine, this suggests that vecuronium may act in part as an open channel blocker at the frog end-plate. Vecuronium depressed both the glutamate response and the excitatory junctional potential at the crayfish neuromuscular junction, although high concentrations were required. The drug increased the decay rate of extracellularly recorded excitatory junctional potentials at the crayfish neuromuscular junction. The reduction of the crayfish synaptic response caused by vecuronium can be explained by the open channel blocking action at this functional site. The problem that cholinergic antagonists possess a property of channel blocking at the other transmitter system was discussed.

• 公益社団法人 日本薬理学会の論文

著者

• Ishida Michiko

  The Tokyo Metropolitan Institute Of Medical Science

• SHINOZAKI HARUHIKO

  The Tokyo Metropolitan Institute of Medical Science

関連論文

• EVALUATION OF EXCITATORY AND INHIBITORY ACTIONS OF GLUTAMATE RELATED COMPOUNDS
• QUISQUALATE ACTION ON THE CRAYFISH NEUROMUSCULAR JUNCTION
• PREVENTION OF DESENSITIZATION OF THE GLUTAMATE RECEPTOR ON THE CRAYFISH OPENER MUSCLE BY CONCANAVALINA
• EXTRACELLULAR EXCITATORY JUNCTIONAL CURRENT AT THE CRAYFISH NEUROMUSCULAR JUNCTION
• AN ATTEMPT AT AN ANALYSIS OF THE FACTORS DETERMINING THE TIME COURSE OF THE GLUTAMATE RESPONSE IN THE CRAYFISH NEUROMUSCULAR JUNCTION
• DEVELOPMENTAL PHARMACOLOGY OF SLOW AND FAST MUSCLES IN THE CHICK
• SYNTHESES OF NEW GLUTAMATE INHIBITORS
• Inhibitory actions of vecuronium bromide on acetylcholine and glutamate responses at the frog and crayfish neuromuscular junction.

スポンサーリンク