AN ATTEMPT AT AN ANALYSIS OF THE FACTORS DETERMINING THE TIME COURSE OF THE GLUTAMATE RESPONSE IN THE CRAYFISH NEUROMUSCULAR JUNCTION

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概要

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• An attempt was made to analyse the factors which might determine the time course of the end-plate current. The end-plate current was measured by clamping the membrane potential of the crayfish muscle fiber. The calculated glutamate-induced current was in good agreement with the observations obtained, suggesting that the presented kinetic model explained well the practical phenomenon. The kinetic model could be applied also to explain the depolarization change induced by prolonged application of glutamate. The semilogarithmic plots of the falling phase of calculated glutamate-induced currents gave an approximately straight line. The slope of the line yielded an apparent desensitization rate constant, and the relationship between the true and apparent desensitization rate constants was determined, but it was suggested that the desensitization rate could not be determined from the slope of the decay of glutamate-induced current alone.

• 公益社団法人日本薬学会の論文

著者

• Ishida Michiko

  The Tokyo Metropolitan Institute Of Medical Science

• SHINOZAKI HARUHIKO

  The Tokyo Metropolitan Institute of Medical Science

関連論文

• EVALUATION OF EXCITATORY AND INHIBITORY ACTIONS OF GLUTAMATE RELATED COMPOUNDS
• QUISQUALATE ACTION ON THE CRAYFISH NEUROMUSCULAR JUNCTION
• PREVENTION OF DESENSITIZATION OF THE GLUTAMATE RECEPTOR ON THE CRAYFISH OPENER MUSCLE BY CONCANAVALINA
• EXTRACELLULAR EXCITATORY JUNCTIONAL CURRENT AT THE CRAYFISH NEUROMUSCULAR JUNCTION
• AN ATTEMPT AT AN ANALYSIS OF THE FACTORS DETERMINING THE TIME COURSE OF THE GLUTAMATE RESPONSE IN THE CRAYFISH NEUROMUSCULAR JUNCTION
• DEVELOPMENTAL PHARMACOLOGY OF SLOW AND FAST MUSCLES IN THE CHICK
• SYNTHESES OF NEW GLUTAMATE INHIBITORS
• Inhibitory actions of vecuronium bromide on acetylcholine and glutamate responses at the frog and crayfish neuromuscular junction.

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