The effect of galactosamine on rat liver cytochrome P-450 activities.

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概要

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• The effect of galactosamine on hepatic drug metabolizing activities was examined in rats. In the microsomal fraction, the contents of cytochrome P-450 (P-450) and cytochrome <I>b</I><SUB>5</SUB> (<I>b</I><SUB>5</SUB>) and the activity of NADPH-cytochrome <I>c</I> reductase (reductase) were examined for 7 days after galactosamine administration. In addition, substrate metabolizing activities in damaged microsomes were examined using four substrates: aminopyrine, aniline, benzo(a)pyrene (B(a)P) and 7-ethoxycoumarine (7-EC). The contents of P-450 and <I>b</I><SUB>5</SUB> and the activity of reductase showed a minimal value after 3 days of galactosamine administration and then gradually increased, reaching to the control level after 7 days. All four substrate metabolizing activities showed a similar response as the content of P-450, but the decrement among the four activities was not uniform. The activities of B(a)P hydroxylation and 7-EC deethylation were more impared than those of aminopyrine demethylation and aniline hydroxylation. This nonuniformity was clear on the activity based on P-450. This result suggested that galactosamine disturbed the population of multiple P-450 subtypes, and each P-450 subtype was damaged to the various extent by galactosamine administration.

• 公益社団法人 日本薬理学会の論文

著者

• SAWAMURA Takaya

  Third Department of Internal Medicine, Kansai Medical University

• Sawamura Takaya

  Third Department Of Internal Medicine Kansai Medical University

• Shiozaki Yasuko

  Third Department Of Internal Medicine Kansai Medical University

• SAMESHIMA Yoshiko

  Third Department of Internal Medicine, Kansai Medical University

• MUBASE Toshihiko

  Third Department of Internal Medicine, Kansai Medical University

• MASUDA Rie

  Third Department of Internal Medicine, Kansai Medical University

• AOI Kazuo

  Third Department of Internal Medicine, Kansai Medical University

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• The effect of galactosamine on rat liver cytochrome P-450 activities.

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