Drug metabolizing activity in rats with chronic liver injury induced by carbon tetrachloride: Relationship with the content of hydroxyproline in the liver.

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概要

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• The drug metabolizing activity of rat liver during long-term administration of carbon tetrachloride (CCl<SUB>4</SUB>), and its relationship with the content of hydroxyproline (Hyp) in the liver were examined. The contents of cytochrome P-450 (P-450) and cytochrome <I>b</I><SUB>5</SUB> (<I>b</I><SUB>5</SUB>) and the metabolization of aniline, aminopyrine, 7-ethoxycoumarin (7-EC) and benzo(a)pyrene (B(a)P) in the microsomal fraction were examined five days after the final administration of CCl<SUB>4</SUB>. The contents of P-450 and <I>b</I><SUB>5</SUB> and the activity to metabolize the four substrates were gradually reduced as the Hyp content in the liver increased. However, aminopyrine N-demethylation and B(a)P hydroxylation, particularly the latter, was more reduced than aniline hydroxylation and 7-EC O-deethylation in the early stage of hepatic fibrosis. Such differences may be due mainly to the different P-450 subtypes affected by CCl<SUB>4</SUB>.

• 公益社団法人 日本薬理学会の論文

著者

• Okuno Hiroyasu

  Third Department Of Internal Medicine Kansai Medical University

• Shiozaki Yasuko

  Third Department Of Internal Medicine Kansai Medical University

• MURASE Toshihiko

  Third Department of Internal Medicine, Kansai Medical University

• HAZAMA Hiroshi

  Third Department of Internal Medicine, Kansai Medical University

• SAMESHIMA Yoshiko

  Third Department of Internal Medicine, Kansai Medical University

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• Drug metabolizing activity in rats with chronic liver injury induced by carbon tetrachloride: Relationship with the content of hydroxyproline in the liver.
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