Suppression of acetaldehyde accumulation by 4-methylpyrazole in alcohol-hypersensitive Japanese.
スポンサーリンク
概要
- 論文の詳細を見る
Alcohol-sensitive Japanese subjects with facial flushing and an increase in heart rate during ethanol intoxication exhibited marked individual variation in accumulation of acetaldehyde. This variation correlated well with the intensity of the above mentioned physiological responses. Oral pretreatment with 10 mg/kg 4-methylpyrazole, which inhibited the ethanol elimination rate by 15-25%, strongly suppressed both acetaldehyde accumulation and the associated responses. Under this condition, the sensitivity to acetaldehyde appeared to be reduced, and the correlation between the acetaldehyde level and the physiological responses disappeared. The effectiveness of even a low dose of 4-methylpyrazole suggests its clinical usefulness for alleviation of acute acetaldehyde toxicity in alcoholhypersensitive Japanese individuals as well as in disulfiram-treated alcoholics.
- 公益社団法人 日本薬理学会の論文
著者
-
Kiriyama Takayuki
Department Of Applied Chemistry Faculty Of Engineering Okayama University
-
Inoue Kazuyoshi
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Osaka University
-
Komura Setsuo
Department Of Legal Medicine Kyoto Prefectural University Of Medicine
-
KERA Yoshio
Department of Civil and Environmental Engineering, Nagaoka University of Technology
-
KERA Yoshio
Department of Legal Medicine, Kyoto Prefectural University of Medicine
-
KIRIYAMA Takayuki
Department of Legal Medicine, Kyoto Prefectural University of Medicine
関連論文
- Enrichment and Characterization of Chlorinated Organophosphate Ester-Degrading Mixed Bacterial Cultures(ENVIRONMENTAL BIOTECNOLOGY)
- Pharmacological Studies of Alcohol Susceptibility and Brain Monoamine Function in Stroke-Prone Spontaneously Hypertensive Rats (SHRSP) and Stroke-Resistant Spontaneously Hypertensive Rats (SHRSR)
- Improved Synthesis and Crystal Structure of TiCl_3 (tmeda) (thf): A Highly Stereoselective Pinacol Coupling Reagent for Aromatic Aldehydes
- Cloning and Expression of the Pyridoxal 5'-Phosphate-Dependent Aspartate Racemase Gene from the Bivalve Mollusk Scapharca broughtonii and Characterization of the Recombinant Enzyme
- Cloning and Expression in Escherichia coli of the D-Aspartate Oxidase Gene from the Yeast Cryptococcus humicola and Characterization of the Recombinant Enzyme
- Isolation of the Cryptococcus humicolus URA3 Gene Encoding Orotidine-5'-Phosphate Decarboxylase and Its Use as a Selective Marker for Transformation (GENETICS, MOLECULAR BIOLOGY, AND GENE ENGINEERING)
- Determination of N-methyl-D-aspartate in tissues of bivalves by high-performance liquid chromatography
- 112. EFFECT OF SELENIUM ON THE TOXICITY OF CADMIUM : REPORT 2 (The Second Meeting for the Study of Toxic Effect)
- Pharmacokinetics of Ethanol Drinking : Absorption Kinetics and First-pass Effect
- The Age of Drinking Onset and Housing Condition Influences Rat Alcohol Drinking Behavior
- The Effects of Neurotoxins 6-Hydroxydopamine and 5,7-Dihydroxytryptamine into the Rat Nucleus Accumbens on the Alcohol Drinking Behavior
- Complete detoxification of tris(1,3-dichloro-2-propyl) phosphate by mixed two bacteria, Sphingobium sp. strain TCM1 and Arthrobacter sp. strain PY1(ENVIRONMENTAL BIOTECHNOLOGY)
- Complete detoxification of tris(2-chloroethyl) phosphate by two bacterial strains : Sphingobium sp. strain TCM1 and Xanthobacter autotrophicus strain GJ10(ENVIRONMENTAL BIOTECHNOLOGY)
- Suppression of acetaldehyde accumulation by 4-methylpyrazole in alcohol-hypersensitive Japanese.
- Complete detoxification of tris(2-chloroethyl) phosphate by two bacterial strains : Sphingobium sp. strain TCM1 and Xanthobacter autotrophicus strain GJ10