Effects of substance P on glycoprotein secretion from acinar cells of the rat submandibular gland.

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概要

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• The action of substance P on glycoprotein secretion from acinar cells of the rat submandibular gland was described in this report. Salivation elicited by i.v. injection of 0.5 to 20 μμg/kg of substance P was increased dose-dependently, and its flow rate was highest at the first 1 min. Major glycoprotein species secreted into saliva by substance P-stimulus were shown to be electrophoretically identical with those found in acini, but not granular convoluted tubules. These results support the view that substance P acts on acinar cells of the submandibular gland and stimulates secretion of saliva from the cells.

• 公益社団法人 日本薬理学会の論文

著者

• Aoki Chihiro

  Department Of Electronics Himeji Institute Of Technology

• MASUHARA Taizo

  Department of Dental Pharmacology, School of Dentistry at Niigata, The Nippon Dental University

• Iwabuchi Yoshiki

  Department of Dental Pharmacology, School of Dentistry at Niigata, The Nippon Dental University

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• Effects of tachykinins on the secretion of fluid and glycoproteins from the submandibular glands of rat, mouse, hamster and guinea pig.
• Effects of metaraminol on the secretion of fluid and glycoproteins from the rat submandibular gland.
• Effects of dobutamine and terbutaline on the secretion of glycoproteins from the acinar cells of the rat submandibular gland.
• Effects of substance P on glycoprotein secretion from acinar cells of the rat submandibular gland.

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