Effects of tachykinins on the secretion of fluid and glycoproteins from the submandibular glands of rat, mouse, hamster and guinea pig.

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概要

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• The effects of substance P, neurokinin A, physalamine, and eledoisin on the secretion of fluid and glycoproteins from the submandibular glands of various rodents were investigated. Following i.v. injection of each peptide at a dose of 20 μg/kg, the major glycoprotein species secreted from rats and guinea pigs were shown to be electrophoretically identical with those found in the acini. However, saliva was not elicited from the mice and hamsters. These results suggest that in both rats and guinea pigs, tachykinins act on the acinar cells of the submandibular gland only.

• 公益社団法人 日本薬理学会の論文

著者

• Aoki Chihiro

  Department Of Electronics Himeji Institute Of Technology

• MASUHARA Taizo

  Department of Dental Pharmacology, School of Dentistry at Niigata, The Nippon Dental University

• Iwabuchi Yoshiki

  Department of Dental Pharmacology, School of Dentistry at Niigata, The Nippon Dental University

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• Sialogogic Effects of Rat Submandibular Gland of Analogs of the C-Terminal Hexapeptide of Substance P.
• A comparative study of the effects of four choline esters on the secretion of fluid and glycoprotein from rat submandibular glands.
• Effects of tachykinins on the secretion of fluid and glycoproteins from the submandibular glands of rat, mouse, hamster and guinea pig.
• Effects of metaraminol on the secretion of fluid and glycoproteins from the rat submandibular gland.
• Effects of dobutamine and terbutaline on the secretion of glycoproteins from the acinar cells of the rat submandibular gland.
• Effects of substance P on glycoprotein secretion from acinar cells of the rat submandibular gland.

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