Cytotoxic Action of Triphenyltin on Mouse Thymocytes: A Flow-Cytometric Study Using Fluorescent Dyes for Membrane Potential and Intracellular Ca2+.

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概要

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• Effects of triphenyltin on mouse thymocytes were examined using fluorescent dyes to monitor membrane potential and intracellular Ca<SUP>2+</SUP>. Triphenyltin at 3 × 10<SUP>-7</SUP> M to 1 × 10<SUP>-6</SUP> M hyperpolarized thymocytes and depolarized them at 3 × 10<SUP>-6</SUP> M or more, associated with increasing intracellular Ca<SUP>2+</SUP>. Hyperpolarization was suppressed by quinine, but not by tetraethylammonium and 4-aminopyridine, suggesting the involvement of Ca<SUP>2+</SUP>-activated K<SUP>+</SUP> current. Triphentyltin failed to hyper-polarize thymocytes in Ca<SUP>2+</SUP>-free solution. Results indicate that triphenyltin promotes Ca<SUP>2+</SUP>-influx to thymocytes. Such an action of triphenyltin may be related to the immunotoxicity of organotins.

• 公益社団法人 日本薬理学会の論文

著者

• Oyama Yasuo

  Department Of Pharmaceutical Care And Clinical Pharmacy Faculty Of Pharmaceutical Sciences Tokushima

• Chikahisa Lumi

  Department of Health Science, Faculty of Integrated Arts and Sciences, The University of Tokushima

• Tomiyoshi Fukiyo

  Department of Health Science, Faculty of Integrated Arts and Sciences, The University of Tokushima

• Hayashi Hiromi

  Department of Clinical Pharmacy, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Japan

• Hayashi Hiromi

  Department of Cardiology, Surugadai Nihon University Hospital

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• Accelerating Action of Quinidine on the Decay Phase of Transient Outward Current in Dissociated Hippocampal Pyramidal Neurons of Rats.
• Cytotoxic Action of Triphenyltin on Mouse Thymocytes: A Flow-Cytometric Study Using Fluorescent Dyes for Membrane Potential and Intracellular Ca2+.
• The Mechanisms of Electroconvulsive Stimuli in BrdU-Positive Cells of the Dentate Gyrus in ACTH-Treated Rats

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