Accelerating Action of Quinidine on the Decay Phase of Transient Outward Current in Dissociated Hippocampal Pyramidal Neurons of Rats.
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概要
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The effect of quinidine on the transient outward current (I<SUB>A</SUB>) in rat hippocampal neurons was studied. Quinidine at 1 × 10<SUP>-6</SUP> M or more dose-dependently decreased the I<SUB>A</SUB> without affecting the current-voltage relationship. Quinidine accelerated the decay phase of the I<SUB>A</SUB>, suggesting the blockade of open channels. This result may have an implication on the side effects of quinidine in the central nervous system, since the I<SUB>A</SUB> is involved in the control of rhythmic electrical activity of the neurons.
- 公益社団法人 日本薬理学会の論文
著者
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Akaike Norio
Department Of Cellular And System Physiology Graduate School Of Medical Sciences Kyushu University
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Oyama Yasuo
Department Of Pharmaceutical Care And Clinical Pharmacy Faculty Of Pharmaceutical Sciences Tokushima
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Akaike Norio
Department of Neurophysiology, Tohoku University School of Medicine
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Harata Nobutoshi
Department of Neurophysiology, Tohoku University School of Medicine
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Oyama Yasuo
Department of Neurophysiology, Tohoku University School of Medicine
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Oyama Yasuo
Department of Health Science, Faculty of Integrated Arts and Sciences, The University of Tokushima
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