Modificational Changes in Function and Morphology of Cultured Macrophages by Geraniin.

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概要

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• Treatment of peritoneal macrophages with geraniin, isolated from <I>Geranium funbergii</I>, markedly induced the phagocytosis of living yeasts. Marked increases in phagocytosis and acid phosphatase activity in macrophage lysates were observed 24 hr after the beginning of geraniin treatment. As observed by electron microscopy, macrophages that had been treated for 24 hr with geraniin had a markedly thickened surface layer which was positive to ruthenium red, compared to the control cells. In addition, geraniin treatment of macrophages appeared to induce remarkably large mitochondria, more coated pits and prominent lysosomal granules. In conclusion, the stimulation of phagocytosis and acid phosphatase activity of macrophages by geraniin treatment may involve alterations of the plasma membrane and cytoplasmic reorganization.

• 公益社団法人 日本薬理学会の論文

著者

• Abe Hiroko

  The Research Institute Of Oriental Medicine Kinki University

• Okuda Takuo

  Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Okayama University

• Ushio Yumiko

  The Research Institute of Oriental Medicine, Kinki University

• Fang Tang

  The Research Institute of Oriental Medicine, Kinki University

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• Effects of Chinese Medicine on Morphological Changes in the Intestinal Villi with Age
• Modificational Changes in Function and Morphology of Cultured Macrophages by Geraniin.
• The Effects of Saikosaponin-d on Yeast Phagocytosis and Degradation in Peritoneal Macrophages: Related Increase in Fc Receptor Expression and Altered Cytoplasmic Organization.

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