The Effects of Saikosaponin-d on Yeast Phagocytosis and Degradation in Peritoneal Macrophages: Related Increase in Fc Receptor Expression and Altered Cytoplasmic Organization.

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概要

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• The effects of saikosaponin-d (ssd), isolated from <I>Bupleurum radix</I>, on phagocytic functions of mouse peritoneal macrophages were investigated in macrophage cultures after treatment in vivo. We also compared the ultrastructural appearances of macrophages from ssd-treated mice with those from control mice. The macrophages from ssd-treated mice showed a significant increase in phagocytosis, intracellular killing of yeast and acid phosphatase activity. Treatment of mice with ssd also induced the Fc receptor expression in macrophages. The macrophages from ssd-treated mice showed more intense spreading on a glass surface than those from the control mice after a 60 min-incubation. Furthermore, the macrophages from ssd-treated mice seemed to possess a well-developed Golgi apparatus and the large vacuoles. The data suggest that the functional changes in the macrophages from ssd-treated mice are brought about by a modification in the surface membrane and the intracellular distribution.

• 公益社団法人 日本薬理学会の論文

著者

• ABE HIROKO

  The Research Institute of Oriental Medicine, Kinki University

• Abe Hiroko

  The Research Institute Of Oriental Medicine Kinki University

• Ushio Yumiko

  The Research Institute of Oriental Medicine, Kinki University

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• The Effects of Saikosaponin-d on Yeast Phagocytosis and Degradation in Peritoneal Macrophages: Related Increase in Fc Receptor Expression and Altered Cytoplasmic Organization.

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