GABAA and GABAB-receptor agonists evoked vagal nerve efferent transmission in the rat.
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概要
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The effect of GABA agonists on vagal efferent activity was studied in anesthetized rats. PCPGABA, a GABA<SUB>B</SUB> agonist (4 and 8mg/kg, s.c.), markedly activated the neural efferent discharge of the vagus. Muscimol, a GABA<SUB>A</SUB> agonist (0.1 and 0.3mg/kg, i.v.), also facilitated vagal activity. Both agonists caused significant gastric acid hyperacidity. Bicuculline (0.25mg/kg, i.v.) or picrotoxin (0.5mg/kg, i.v.) given 10 min prior to each agonist had no effect on the frequency of vagal nerve firing elicited by PCPGABA (4mg/kg, s.c.) or muscimol (0.3mg/kg, i.v.). Pretreatment with scopolamine (0.25mg/kg, i.v.) abolished PCPGABA stimulated vagal activity and gastric acid secretion. Methscopolamine (0.25mg/kg, i.v.) inhibited only the hyperacidity evoked by PCPGABA, but not vagal activation. These results suggest that PCPGABA and muscimol may cause gastric acid secretion through central cholinergic descending mechanisms that are resistant to GABA<SUB>A</SUB> and GABA<SUB>B</SUB> antagonists.
- 公益社団法人 日本薬理学会の論文
著者
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Hara Nobuyuki
Research Institute For Disease Of The Chest Faculty Of Medicine Kyushu University
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Hara Youichi
Research Center Sumitomo Pharmaceuticals Co.
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Goto Yoshiaki
Department Of Agricultural Chemistry Nagoya University
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Yamasaki Katsuya
Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.
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Hara Youichi
Research Laboratories, Sumitomo Phamaceuticals Co.
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Hara Nobuyuki
Research Laboratories, Sumitomo Phamaceuticals Co.
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