Stable Prostaglandin I_1 Analog SM-10906 Modulates Productions of Tumor Necrosis Factor-α, Interleukin-1 and Interleukin-6 in Mouse Macrophages
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概要
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The present study investigated the effects of stable agonist for prostaglandin (PG) I_2 receptor with PGI_1 skeleton, SM-10906,on pro-inflammatory cytokine production by mouse peritoneal macrophages (PEMs) in comparison with PGE_1 and PGI_2. In mouse PEMs, SM-10906 and PGE_1 slightly enhanced interleukin (IL)-6 secretion, but had no effects on tumor necrosis factor-α (TNF-α) or IL-1 production. SM-10906 concentration-dependently inhibited TNF-α, IL-1 and IL-6 releases from lipopolysaccharide-activated mouse PEMs, as with PGE_1,PGI_2 and cAMP analog. Additionally, SM-10906,PGE_1 and PGI_2 caused concentration-dependent accumulation of cAMP contents in mouse PEMs. It is concluded that PGI_1 analog SM-10906 exerts anti-inflammatory effects on stimulated mouse PEMs by increasing in cAMP levels, as with E-series of PG.
- 公益社団法人日本薬学会の論文
- 2000-06-01
著者
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Ueda Y
Research Center Sumitomo Pharmaceuticals Co.
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NISHIMURA Takeshi
Research Center, Sumitomo Pharmaceuticals Co.,
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YAMAMOTO Takaaki
Research Center, Sumitomo Pharmaceuticals Co.,
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UEDA Yutaka
Research Center, Sumitomo Pharmaceuticals Co.,
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YAMADA Kimiko
Research Center, Sumitomo Pharmaceuticals Co.,
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HARA Youichi
Research Center, Sumitomo Pharmaceuticals Co.,
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Yamada Kimiko
Research Center Sumitomo Pharmaceuticals Co.
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Yamamoto Takaaki
Research Center Sumitomo Pharmaceuticals Co.
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Yamamoto Takaaki
Research Center Sumitomo Pharmaceutical Co. Ltd.
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Hara Youichi
Research Center Sumitomo Pharmaceuticals Co.
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Nishimura Takeshi
Research Center Sumitomo Pharmaceuticals Co.
関連論文
- Stable Prostaglandin I_1 Analog SM-10906 Modulates Productions of Tumor Necrosis Factor-α, Interleukin-1 and Interleukin-6 in Mouse Macrophages
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