Binding Profile of SM-9018, a Novel Antipsychotic Candidate
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概要
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The present study employed various receptor-binding assays to clarify the biochemical characteristics of SM-9018. SM-9018 possessed very high affinity for 5-HT<SUB>2</SUB>, D<SUB>2</SUB> and 5-HT<SUB>1A</SUB> receptors (K<SUB>1</SUB>=0.61, 1.4 and 2.9 nM, respectively), and it had moderate affinity for α<SUB>1</SUB>, and D<SUB>1</SUB> receptors (K<SUB>1</SUB>=17 and 41 nM, respectively). However, SM-9018 had only negligible affinity for α<SUB>2</SUB>, opiate, glutamate, phencyclidine, benzodiazepine and GABA<SUB>A</SUB> receptors. These results suggest that SM-9018 may be a novel antipsychotic agent with binding affinity for 5-HT<SUB>2</SUB> and 5-HT<SUB>1A</SUB> receptors.
著者
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SHIMIZU Hiroshi
Research Institute for Polymers and Textiles
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NAKAMURA Mitsutaka
Research and Development Center, Pharmaceuticals Division, Sumitomo Chemical Co., Ltd.
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Hirose Akira
Research Center For Advanced Science & Technology University Of Tokyo:dept.of Frontier Informati
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TANAKA Hiroyasu
Research Laboratories, Sumitomo Pharmaceuticals, Co., Ltd.
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TANAKA Hiroyasu
Research Laboratories, Sumitomo Pharmaceuticals Co., Ltd.
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KATO Terufumi
Research Laboratories, Sumitomo Pharmaceuticals, Co., Ltd.
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KATO Terufumi
Research Laboratories, Sumitomo Pharmaceuticals Co., Ltd.
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OHNO Yukihiro
Research Laboratories, Sumitomo Pharmaceuticals, Co., Ltd.
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OHNO Yukihiro
Research Laboratories, Sumitomo Pharmaceuticals Co., Ltd.
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NAKAMURA Mitsutaka
Research Laboratories, Sumitomo Pharmaceuticals, Co., Ltd.
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HIROSE Akira
Research Laboratories, Sumitomo Pharmaceuticals, Co., Ltd.
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SHIMIZU Hiroshi
Research Laboratories, Sumitomo Pharmaceuticals, Co., Ltd.
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