Autoradiographic evidence for the interaction of SM-3997 with 5-HT1A receptors in the rat brain.
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概要
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[<SUP>3</SUP>H]8-OH-DPAT binding to rat brain sections and inhibition by SM-3997 were investigated. Very high densities of [<SUP>3</SUP>H]8-OH-DPAT binding sites were found in the dentate gyrus, entorhinal cortex, dorsal raphe, interpeduncular nucleus and lateral septum. In contrast, their densities were sparse in the substantia nigra, caudate putamen and choroid plexus. In the presence of 1 μM of SM-3997, [<SUP>3</SUP>H]8-OH-DPAT binding was strongly inhibited in all the brain structures we examined. These results indicate that SM-3997 binds to 5-HT<SUB>1A</SUB> receptors of rat brain sections.
- 公益社団法人 日本薬理学会の論文
著者
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SHIMIZU Hiroshi
Research Institute for Polymers and Textiles
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NAKAMURA Mitsutaka
Research and Development Center, Pharmaceuticals Division, Sumitomo Chemical Co., Ltd.
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Hirose Akira
Research Center For Advanced Science & Technology University Of Tokyo:dept.of Frontier Informati
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KUMASAKA Yoshino
Research Laboratories, Sumitomo Pharmaceutical Co., Ltd.
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TANAKA Hiroyasu
Research Laboratories, Sumitomo Pharmaceuticals Co., Ltd.
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Tatsuno Tohru
Research Laboratories, Sumitomo Pharmaceuticals Co., Ltd.
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Kumasaka Yoshino
Research Laboratories, Sumitomo Pharmaceuticals Co., Ltd.
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