Interaction of SM-3997 with Serotonin Receptors in Rat Brain
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概要
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The propensity of SM-3997 to displace <SUP>3</SUP>H-ligands was tested in vitro in a number of receptor-binding assays. SM-3997 possessed a high affinity towards 5-HT<SUB>1A</SUB> receptors, low affinity towards dopamine (D<SUB>2</SUB>) and 5-HT<SUB>2</SUB> receptors, and no affinity towards benzodiazepine (BZ), GABA, 5-HT<SUB>1B</SUB> and adrenergic receptors. Moreover, SM-3997 facilitated neither <SUP>3</SUP>H-flunitrazepam binding nor <SUP>3</SUP>H-muscimol binding. These results suggest that the action of SM-3997 may be mediated via central 5-HT<SUB>1A</SUB> receptors but not the BZ-GABA receptor complex.
著者
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SHIMIZU Hiroshi
Research Institute for Polymers and Textiles
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NAKAMURA Mitsutaka
Research and Development Center, Pharmaceuticals Division, Sumitomo Chemical Co., Ltd.
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Hirose Akira
Research Center For Advanced Science & Technology University Of Tokyo:dept.of Frontier Informati
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KUMASAKA Yoshino
Research Laboratories, Sumitomo Pharmaceutical Co., Ltd.
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TANAKA Hiroyasu
Research Laboratories, Sumitomo Pharmaceuticals Co., Ltd.
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Tatsuno Tohru
Research Laboratories, Sumitomo Pharmaceuticals Co., Ltd.
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KARAI Nobuyuki
Research Laboratories, Sumitomo Pharmaceuticals Co., Ltd.
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