Properties of phenytoin binding sites in the rat brain: Regional distribution and postnatal development.

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概要

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• Specific [<SUP>3</SUP>H]phenytoin binding in rat cortical membranes is associated with a micromolar affinity site through which diazepam can exert an enhancing effect. In contrast to diazepam, (+)bicuculline, isoguvacine and pentobarbital inhibited phenytoin binding, while GABA and (-)baclofen had no effect. Decreased phenytoin binding and a loss of the diazepam effect were observed in phospholipase A<SUB>2</SUB>-treated membranes. Binding in the absence and presence of diazepam demonstrated differential postnatal development. Furthermore, the degree to which binding was enhanced by diazepam varied from one brain region to another. The regional variations of phenytoin binding, both in the presence and absence of diazepam, did not correlate positively with the regional distribution of either the central benzodiazepine receptors or the peripheral type binding sites in the brain.

• 公益社団法人 日本薬理学会の論文

著者

• Wong Peter

  Department Of Diagnostic Neurophysiology B.d. Children's Hospital

• Teo Wee

  Department Of Cardiology National Heart Centre

• TEO Wee

  Department of Pharmacology, Faculty of Medicine, National University of Singapore

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