Phorbol ester potentiates .ALPHA.1-adrenoceptor-mediated positive inotropic effect in rat papillary muscle.
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概要
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Tumor-promoting phorbol esters may alter α<SUB>1</SUB>-adrenoceptor-mediated cardiac response by stimulating protein kinase C activity. We investigated the effect of phorbol-12, 13-dibutyrate (PDBu) on the positive inotropic effect (PIE) in rat left ventricular papillary muscle. PDBu (1-100 nM) potentiated the phenylephrine (PE)-induced PIE in a dose and time-dependent manner. The PIE induced by PE and PDBu was abolished by pretreatment with 3×10<SUP>-7</SUP> M prazosin. PDBu also enhanced PE-induced slow responses 2- to 3-fold. These results suggest that PDBu enhances α<SUB>1</SUB>-adrenoceptor mediated PIE by potentiating slow Ca<SUP>2+</SUP> channels, presumably through the activation of protein kinase C.
- 公益社団法人 日本薬理学会の論文
著者
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Otani Hitomi
Department Of Pharmacology Kansai Medical University
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Otani Hajime
Department Of Crop And Animal Science Faculty Of Agriculture Shinshu University
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OTANI Hajime
Department of Thoracic Surgery, Kansai Medical School
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DAS Dipak
Cardiovascular Laboratory, Department of Surgery, University of Connecticut School of Medicine
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