Alpha-Human Atrial Natriuretic Peptide (α-hANP) Prevents Pulmonary Edema Induced by Arachidonic Acid Treatment in Isolated Perfused Lung from Guinea Pig
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概要
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Protective effect of α-human atrial natriuretic peptide (α-hANP) on pulmonary edema was investigated using an isolated perfused lung model. Infusion of α-hANP (1.7 to 22 ng/ml or 0.56 to 7.3 nM) prevented the edema induced in isolated lung from guinea pig by repeated treatment of 50 μg of arachidonic acid at 30 min intervals via the pulmonary artery. The antiedematic action of α-hANP was considered to be receptor mediated because the effective concentration was close to the K<SUB>d</SUB> value of the binding of the ANP receptors in the lung homogenate.
著者
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Inomata Norio
Suntory Institute for Biomedical Research
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Ishihara Takafumi
Suntory Institute For Biomedical Research Wakayamadai
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NOGUCHI Teruhisa
Suntory Institute for Biomedical Research
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FURUYA Mayumi
Suntory Institute for Biomedical Research
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MATSUO Hisayuki
Department of Biochemistry, Miyazaki Medical College
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MATSUO Hisayuki
Department of Biochemistry, Miyazaki College of Medicine
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KANAI Yasushi
Suntory Institute for Biomedical Research
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OHNUMA Norio
Suntory Institute for Biomedical Research
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HAYASHI Yujiro
Suntory Institute for Biomedical Research
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ISHIHARA Takafumi
Suntory Institute for Biomedical Research
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