Phantom experiment and analysis for in vivo measurement of boron-10 concentrations in melanoma for boron neutron capture therapy.
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概要
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In the present work, we examined the possibility of in vivo measurement of <SUP>10</SUP>B concentrations in dermal tumor for boron neutron capture therapy. Until now, the microanalysis system of ppm-order <SUP>10</SUP>B concentrations in tissue has been already established for small samples including tissue from the measurement of the ratio of prompt γ-rays emitted from <SUP>10</SUP>B (n, αγ)<SUP>7</SUP>Li reactions and from H(n, γ)D reactions, by using the thermal neutron beam at the KUR Neutron Guide Tube. In the application to a human body, unlike a small sample of homogeneous medium of <SUP>10</SUP>B and H, the <SUP>10</SUP>B/H Gamma-ray Counting Ratio depends mainly on (1) the neutron flux distributions in a body, (2) the shape and size of tumor and (3) the neutron beam position on tumor. Then, we carried out phantom experiments in order to study the relation among those factors. On the other hand, we developed a calculation method for estimating <SUP>10</SUP>B/H Gamma-ray Counting Ratio and for investigating general tendency among those factors. In calculations, DOT 3.5 and MORSE-MT were used for the calculation of neutron flux distributions and a hand-made program named BORAD was developed to calculate the <SUP>10</SUP>B/H Gamma-ray Counting Ratio by using the former neutron flux distributions. As a results of these experiments and calculations, it proved to be possible to know <SUP>10</SUP>B concentrations in dermal tumor, of which volume was known in advance, within 20% permissible accuracy for boron neutron capture therapy.
- 一般社団法人 日本原子力学会の論文
著者
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Kobayashi Tooru
Research Reactor Inst. Kyoto Univ.
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KANDA Keiji
Research Laboratory of Nuclear Reactor, Tokyo Institute of Technology
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AOKI Kazuhiko
Research Reactor Institute, Kyoto University
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- Phantom experiment and analysis for in vivo measurement of boron-10 concentrations in melanoma for boron neutron capture therapy.