喉頭癌発癌母地に関する病理組織学的研究(発癌の場としての価値考察)
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Histopathological investigations on the epithelium of the entire larynx were performed to study the origins of laryngeal carcinoma. The research objects were 45 larynges removed from patients with glottic cancer and 56 larynges from patients with supraglottic cancer. The controls were 59 normal larynges from autopsy cases.The squamous metaplasia of the laryngeal epithelia was investigated using the gross staining methods (pyronin Y and alcian blue/phlpxine stainings) of Stell et al. The squamous metaplasia of the supraglottic region was divided into five types: I, the infantile metaplasia type; II, the marginal metaplasia type; III, the island-like metaplasia type; IV, the wide field type; and V, the total metaplasia type. The metaplasia of the subglottic region was divided into two types; the continuous metaplasia type and the island-like metaplasia type.In the controls, the metaplasia was found to have progressed with aging in the supraglottic region. In the supraglottic cancer group, the metaplasia of the supraglottic region was in high degree in contrast with the controls and glotticcancer group. The metaplaplasia was a little stronger in the glottic cancergroup than in the controls. No relation was found between the progress of the cancer and that of metaplasia.Of the larynges subjected to the grass staining method, serial sections were prepared from 47 and these sections were studied microscopically. Most of theepithelia showed stable metaplasia, but there were various types of dysplasia in part. This finding was often seen in the supraglottic region of larynges from supraglottic cancer cases and in the non-cancerous vocal cords in larynges from glottic carcinoma cases.From these results, it can be assumed that the metaplasia in the supraglottic region plays a major role in outbreaks of supraglottic carcinoma.
- 社団法人 日本耳鼻咽喉科学会の論文