Wegener 氏肉芽腫症について : 所謂進行性壤疽性鼻炎の文献的考察

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1) The clinical and histological findings on four cases of W. G. and its literatures are described in this paper.2) W. G. is a general systemic disease of which characteristic trias are as follows;a) the nasal progressive necrotizing process, b) the general vascular diseases and the granulomatous processes in many visceral organs, andc) the glomerulonephritic process in the kidney.3) The clinical symptoms of the affected organs are very variable, once appearing simultaneously as a general septicemic disease, but often appears independently one after another, being treated as a localised illness.4) The histological findings of these cases are in general similar to those of the typical description of W. G., but it must be noted that there are some differences according to each affected organ and to each clinical stage. In two of our four cases marked acellulous fibrostic process was seen.5) The fibrinoid change and the glomerulonephritic process, both of which many be considered characteristic for the collagen disease, were also observed in our cases. These findings indicate that among the many complex pathogenic factors of W. G., there may be some same or common factors as those of the collagen disease.6) The clinical prognosis of W. G. is not good. As for the therapeutic procedure for this malignant disease, the cortico-steroid, Decadron, is the most effective, but since its effect is limited, it may not be considered as having an essential therapeutic effect.
社団法人日本耳鼻咽喉科学会の論文

Wegener 氏肉芽腫症について : 所謂進行性壤疽性鼻炎の文献的考察

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