Carcinoembryonic Antigen Levels in Peritoneal Washings from Colorectal Cancer Patients as a Predictor for Peritoneal Disseminating Metastasis.

概要

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Carcinoembryonic anigen (CEA) levels were determined in the peritonael washings from 52 patients with colorectal cancer. Elevated values (>100ng/g protein) were observed in 19 of 27 patients with colon cancer and 8 of 25 patients with rectal cancer. The positive rate of elevated CEA legels was significant higher, 71.4%, in 42 patients with serosal invasion, when compared with 10% in patients with cancer limited in muscularis propria. No positive case was observed in patients with rectal cancer located in low part of rectum.<BR>The positive rate was obtained from 41.5% of the patients without peritoneal metastasis which was significant lower compared with 90.9% (10 of 11) patients with peritoneal dissemi-nating metastasis.<BR>Positive cytology was obtained from only 5, who had macroscopic peritoneal dissemination. The levels of CEA in serum did not affect those in peritoneal washings.<BR>In conclusion, we have found the CEA levels in peritoneal washings could be a sensitive detector of serosal invasion and micro dissemination.
日本大腸肛門病学会の論文