Overexpression of p53 in Colorectal Tumors: An Immunohistochemical Study.

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The overexpression of p53 was determined immunohistochemically, using an avidinbiotin peroxidase method with anti p53 mouse monoclonal antibody (PAb-1801), in 81 carcinomas, 36 adenomas, and 42 normal mucosae of the colorectum.<BR>Intense immunoreactivity for p53 was detected in 44 carcinomas (54.3 %), in 4 adenomas (11.1 %), while no staining for p53 was demonstrated in normal mucosae.<BR>The overexpression of p53 was significantly more often detected in carcinomas than in adenomas (p<0.01) and normal mucosae (p<0.01), and it was significantly more often detected in adenomas than normal mucosae (p<0.05).<BR>There was no correlation between the overexpression of p53 and clinicopathlogical variables except liver metastasis (p<0.05). The immunoreactivity for p53 did not correlate with DNA aneuploidy of colorectal carcinomas. These results sugget that p53 is implicated in the late step in colorectal tumorigenesis, but is not implicated in the progression of overt colorectal carcinomas.
日本大腸肛門病学会の論文