Intra-operative Pelvic Hyperthermochemotherapy as an Adjuvant Therapy for Dukes' C, Lower Rectal Cancer.

概要

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During the 6 years period from 1985 to December 1990, we had done curative resection in 31 patients with Dukes' C, lower rectal cancer.<BR>Of 31, fifteen patients were perscribed intraoperative pelvic hyperthermochemotherapy (IOPHC) as an adjuvant therapy to prevent local recurrence, and effects of IOPHC on preventing local recurrence and distant metastasis were evaluated, comparing with 16 patients undergoing surgery alone (control group).<BR>The procedure of IOPHC was as follows : After removal of the rectum, the pelvic cavity was filled with pre-warmed physiological saline, contaning mitomycin C of 40 μg/ml, and the saline was warmed at 45°C for 90 minutes by an apparatus we devised for IOPHC. The local recurrence has developed in 7 cases of control group (7/16: 43.8 %), and in 2 cases (2/15: 13.3 %) of IOPHC group. On the other hand, distant metastasis occured at the approximately same rate, 4 cases in each group.<BR>IOPHC is a safe and feasible adjuvant therapy for preventing local recurrence of curatively resected Dukes' C, lower rectal cancer.
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