Intratumoral DNA Heterogeneity in Colorectal Cancer and its Relationship to Clinicopathological Findings and Prognosis.

概要

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The purpose of our study is to examine the relationship between intratumoral DNA heterogeneity in colon cancer and clinicopathological findings and prognosis.<BR>A series of 31 patients with colon cancer was studied. Four samples from the different sites of each tumor were subjected to DNA measurement by static cytofluorometry. When there were multiple peaks in one tumor which varied by more than 10% in DNA index the tumors were defined as heterogeneity.<BR>Seventeen (54.8 %) of 31 patients were found to have heterogeneity tumors. As compared with homogeneity, heterogeneity tumors showed a tendency for deeper invasion, liver metastasis and more advanced staging. The patients with heterogeneity tumors had poorer prognosis than the those with homogeneity tumors. And this tendency was remarkable in stage III-V cases.<BR>These data might suggest that the intratumoral DNA heterogeneity is possible to be an indicator of liver metastasis and prognosis in patients with colon cancer.
日本大腸肛門病学会の論文