Relationship between Histological Effects of Preoperative Radiation upon Rectal Cancer and its Operative Results.

概要

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Fifty three cases of rectal cancer with preoperative radiation (a total dose of 42.6 Gy) were classified into two groups according to its histological effects: 1) marked effective group (28 cases); 2) non-effective group (25 cases). Thereafter, operative results of two groups were studied comparatively. In marked effective group, histological factors predictive of risk of local recurrence consisting of depth of invasion, ew (distance between surgical surface and tumor invasion) and frequency of lymph node metastasis, have favorably changed compared with those of non-effective group with statistical significance. As a consequence, local recurrence rate of marked effective group was 3.6% as compared to 12.0% in non-effective group. Furthermore, duration between the time of recurrence and initial operation tended to be prolonged in marked effective group. In cumulative survival rate, there was a significant difference between the two groups (marked effective group; 87.7%, noneffective group; 57.9%).<BR>These results lead to the following conclusions: 1) histological effects of radiation had a close association with results of operation; 2) it was suggested that getting higher radiation effects would be important in treatment of rectal cancer.
日本大腸肛門病学会の論文