Lymphatic spread of rectal cancer and peirectal lymphatics examined by BrdU-labeled lymphocytes. : Lymphatics Examined by BrdU-labeled Lymphocytes

概要

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From January 1980 to May 1988, 163 patients with rectal cancer were tested clinicopathologically for lymphnode metastasis and perirectal lymphatics were examined with BrdU-labeled lymphocytes in 22 atients with rectal cancer from May 1987 to May 1988 to establish the indicatins for lymphnode dissection. <BR>1) The main metastatic route of rectal carcinoma was to the upper lymphnodes. Upward lymph flow was the main pathway within the rectum. <BR>2) Lateral lymphnode metastasis was frequentry food in the carcinoma which anal edge were below the peritoneal reflection. Not only upward lymph flow but also lateral lymph flow was found in this region. <BR>3) The clinicopathological factors which significantly influenced lymphnode metastasis were : the depth of penetration, histological type and lymphatic invasion. Penetration was deeper, only the incidence of lymphnode metastasis was higher. The incidence of lymphnode metastasis was higher in poorly and moderately differentiated adenocarcinoma than in well differentiated adenocarcinoma. The incidence of lymphnode metastasis correlated well with the degree of lymphatic invasion.