Immunohistochemical study on secretory component, IgA and CEA in gastrointestinal lesion with special reference to the Cronkhite-Canada syndrome.

概要

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An immunohistochemical study on secretory component (SC), IgA and CEA were performed using the PAP method in several kinds of gastrointestinal lesion. In general, colonic mucous membrane showed increased staining for these factors compared with gastric mucosa. Decreased staining for SC and IgA, contrary to an increase in that for CEA, was found in cancerous tissue. Some correlation between CEA staining and histologic dysplasia was found in colonic polyposis. Decreased staining for SC and IgA was found in juvenile polyp and adenoma in the Cronkhite-Canada syndrome, suggesting a decrease in the production of SC and in the secretory function of IgA. In addition, the possibility of malignant change was suspected immunohistochemically in the case with intestinal metaplasia adenoma. These findings indicate that an immunological mechanism might be expected to play a role in the development of the Cronkhite-Canada syndrome.
日本大腸肛門病学会の論文