閉塞性大腸炎の成因に関する臨床病理学的研究

概要

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The present study was conducted in order to evaluate the mechanism of ulcer formation in obstructive colitis and thus to elucidate the pathogenesis of this disease. Fourteen cases of ulcers including erosion (U1-I) on the oral side of colon cancer ‹U1 (+) group› were studied in comparison with 72 cases without ulcer ‹U1 (-) group›. All cases in the U1 (+) group had symptoms due to the colic obstruction. Histologically, severe edema, congestion and infiltration of inflammatory cell in layers deeper than the submucosal layer around the ulcer were found in all cases in the Ul (+) group, and fibrous intimal hyperplasia and vacuolar degeneration of smooth muscle cells in the tunica media of the small mesenteric arteries were found in 8 cases. In the Ul (-) group, the frequency of these histological changes was correlated with the severity of the obstructive symptoms. Moreover, ulcers were found at a high frequency in cases with spastic symptoms.<BR>These findings suggested that the consequent ischemia of the intestinal wall resulted from the vascular changes and that the intestinal spasm due to persistent intestinal obstruction might play an important role in the formation of ulcers in obstructive colitis.
日本大腸肛門病学会の論文