The close relation-ship between two major immunoresponse gene (HLA and Gm) and the colo-rectal cancer.

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Human immunoresponse gene (Ir-gene) comes in two kinds, namely, one that links with the 6th chromosome HLA complex and the other that links with the structural gene (Gm) of the 14th chromosome immunoglobulin H chain. The relationship between these chromosomes and cancer of the colon was studied. Gm allotype was determined by the blood corpuscle agglutination test in 154 cases (control : 313 cases) of cancer of the colon and HLA by the cytotoxicity test in 135 cases (control : 310 cases) of cancer of the colon. As a result, the proportion of HLA-CW3 (control 46%) was significantly high at 80% in cancer of the colon (x2=44.6, rr=4.7). As for Gm, the proportion of axg and ab035st were significantly high in cancer of the colon. These results suggest that axg and ab035st are antigenes sensitive to cancer of the colon. In 50 cases of cancer of the colon, in which two tests were performed, 64% (control 19%) had both of these antigens. This percentage is significantly higher than that for the cases which had neither of these antigens (x2=305, rr=13.1). Statistically, therefore, it is clear that Gm allotype colon cancer sensitive antigen is more important as a factor concerned with the development of cancer of the colon than HLA-colon cancer sensitive antigen.
日本大腸肛門病学会の論文