Elevated Serum Interleukin-6 in POEMS Syndrome Reflects the Activity of the Disease.

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概要

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• In patients with POEMS syndrome, which often accompanies plasma cell dyscrasia, the roles of interleukin-6 (IL-6) and other acute phase cytokines are unknown. Serum IL-6, interleukin-1β; (IL-1β) and tumor necrosis factor-β (TNF-α) were measured by the enzyme-linked immunosorbent assay technique in 16 patients with POEMS syndrome and in patients with other neurological diseases (OND) as control. Serum IL-6 was more frequently detected and higher in active POEMS than in stable POEMS or in OND patients. No sample was positive for IL-1β. TNF-α; was positive in 3 out of 7 active POEMS patients, but its significance was not definite. Serum IL-6 levels in POEMS patients reflected the disease activity but not the severity of accompanying plasma cell dyscrasia.(Internal Medicine 33: 583-587, 1994)

• 社団法人　日本内科学会の論文

著者

• Sakuta Manabu

  The Department Of Neurology Japanese Red Cross Medical Center

• SUZUKI Kenshi

  The Department of Hematology, Japanese Red Cross Medical Center

• HITOSHI Seiji

  the Department of Neurology, Japanese Red Cross Medical Center

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• Elevated Serum Interleukin-6 in POEMS Syndrome Reflects the Activity of the Disease.

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