1. Hypertension and Genes
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概要
- 論文の詳細を見る
Under classical strategy, scientists have tried first to find a physiological phenomenon specific for essential hypertension, then to identify the protein underlying the physiological abnormality, and finally to clarify the causative gene which encoded the protein. On the other hand, under the reverse genetic approach, the correlation between hypertension and genetic abnormality is identified first, and then the pathogenesis is clarified-in reverse order. Therefore, it is not extraordinary for unexpected results to be obtained in the correlation between a gene and a disease, suggesting that this approach has a possibility to be a breakthrough in the chaos of hypertension research.
- 社団法人 日本内科学会の論文
著者
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Morishita Ryuichi
the Department of Geriatric Medicine, Keio University School of Medicine
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Higaki Jitsuo
the Department of Geriatric Medicine, Keio University School of Medicine
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Ogihara Toshio
The Department Of Geriatric Medicine Osaka University Medical School
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Morishita Ryuichi
Division Of Gene Therapy Science Osaka University Graduate School Of Medicine
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Katsuya Tomohiro
The Department Of Geriatric Medicine Osaka University Medical School
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HIGAKI Jitsuo
The Department of Geriatric Medicine, Osaka University Medical School
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Ogihara Toshio
The Department of Geriatric Medicine, Osaka University Medical School
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KATSUYA Tomohiro
The Department of Geriatric Medicine, Osaka University Medical School
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MORISHITA Ryuichi
The Department of Geriatric Medicine, Osaka University Medical School
関連論文
- Prevention of osteoporosis by angiotensin-converting enzyme inhibitor in spontaneous hypertensive rats
- Genetic basis of hypertension for the development of tailored medicine
- OE-071 A Genom-Wide Association Study of SNPs in the risk of Atherosclerosis Obliterans(Heart failure, clinical(01)(M),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- DPJ-013 Hepatocyte Growth Factor Attenuates TGF-β1 Angiotensin II Crosstalk by Down Regulation of Angiotensin II Type 1 Receptor through PTEN/Akt Pathway(DPJ03,Kidney/Renal Circulation/CKD (H),Digital Poster Session (Japanese),The 73rd Annual Scientific M
- Catheter-Delivered In Vivo Gene Transfer into Rat Myocardium Using the Fusigenic Liposomal Mediated Method
- Association of Mast Cell Chymase Gene Variant with HDL Cholesterol, but not with Blood Pressure in the Ohasama Study
- Variation in OSBPL10 is associated with dyslipidemia
- Serum hepatocyte growth factor concentration is a specific marker of endothelial dysfunction in humans
- Association of Serum Oxidized Lipoprotein(a) Concentration with Coronary Artery Disease : Potential Role of Oxidized Lipoprotein(a) in the Vasucular Wall
- PJ-042 Pivotal Roles of CYLD (cylindromatosis) as a Deubiquitinating Enzyme in Vasculature(Atherosclerosis, basic(05)(IHD),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Recognition of Tissue- and Subtype-Specific Modulation of Angiotension II Receptors Using Antibodies against AT_1 and AT_2 Receptors
- Symposium on The Etiology of Hypertension - Summerizing Studies in 20th Century -, Hypertension and Genes
- Influence of Aging on Progression of Cardiovascular Complications Associated with Insulin Resistance in Patients with Essential Hynertension
- Lack of Association between the Hepatocyte Growth Factor Receptor, c-met, and the Anti-Apoptotic Action of Bag-1 in Endothelial Cells
- Recovery of Learning and Memory by Gene Therapy Using Hepatocyte Growth Factor Gene After Focal Cerebral Ishcemia in Rats(Gene Therapy/Genetic Engineering (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Gene Polymorphism of Myospryn (Cardiomyopathy-Associated 5) Is Associated with Left Ventricular Wall Thickness in Patients with Hypertension
- Inhibitory Effect of Chimera Decoy Oligodeoxynucleotides (ODN) against Ets and NFκ B on the Progression of Rabbit Experimental Aortic Aneurysms (AAA)
- Gene Therapy for Abdominal Aortic Aneurysm (AAA) using Decoy Strategy against ets binding site
- Effect of E2F decoy on inhibitation of neointima formation in pig coronary arteries after balloon injury and stent implantation
- Transcription factor, ets-1, is a novel angiogenic molecule : Implication to ciene therapy to treat peripheral arterial disease
- Novel molecular intervention to treat abdominal aortic aneurysms (AAA) using chimera decoy oligodeoxynucleotides (ODN) against ets and NFkB binding sites
- Therapeutic Angiogenesis Induced by Endotherial Nitric Oxide Synthase Gene through VEGF Expression in Rat Hindlimb Ischemia Model
- Polymorphism of myospryn is associated with left ventricular diastolic dysfunction
- Increase in DNA Synthesis of Cardiac Myocytes by Transfection ofP53 and Rb Antisense : Possibility of Cardiac Myocytes Regeneration
- PJ-145 Periostin as a Novel Therapeutic Target for Heart Failure(Acute coronary syndrome, basic/clinical-7, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-024 New Mechanisms of an Angiotensin Receptor Blocker, Valsartan, on the Heart Failure through the Inhibition of Novel Anti-adhesion Molecule, Periostin(Heart failure, basic-2 (M) OJ4,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific
- Periostin as a Anti-adhesion Molecule Responsible for Ventricular Dilation(Heart Failure, Basic 3 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- BLOOD PRESSURE RESPONSE TO [1-SARCOSINE, 8-ISOLEUCINE]ANGIOTENSIN II IN PATIENTS WITH LIVER CIRRHOSIS AND ASCITES
- IS030 Antisense bcl-x Oligonucleotide Induces Apoptosis and Prevents Arterial Neointimal Formation in Murine Cardiac Allografts
- IS030 Prevention of Cardiac Allograft Arteriosclerosis with Single Intraluminal Delivery of Decoy to Transcription Factor E2F
- FRS-003 Docking Protein Gab1 is Essential for HGF-dependent Endothelial Signaling and Angiogenesis after Hindlimb Ischemia(FRS1,New Molecules for Cardiovascular Regulation (M),Featured Research Session (English),The 73rd Annual Scientific Meeting of The J
- OE-206 Development of Ribbon Type NF-κ B Decoy Oligodeoxynucleotides(Genetics/Genetically engineered models/Gene therapy-1(H/M), The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Nonviral HVJ (hemagglutinating virus of Japan) liposome-mediated retrograde gene transfer of human hepatocyte growth factor into rat nervous system promotes functional and histological recovery of the crushed nerve
- PE-062 Zyxin Progresses Epithelial-Mesenchymal Transition under the Control of Twist1 and Contributes to Endocardial Morphogenesis(PE011,Congenital Heart Disease (M),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation S
- IS023 Antisense Proliferating-cell Nuclear Antigen Oligonucleotide Attenuates Cardiac Allograft Arteriopathy
- PJ-086 Regression of Experimental Rabbit Aortic Aneurysm by The Treatment with Chimera Decoy Oligodeoxynucleotides (ODN) against ets and NFkB(Gene Therapy 1 (IHD) : PJ15)(Poster Session (Japanese))
- OJ-094 Delayed Post-ischemic Treatment with Fluvastatin Improved Learning and Memory Deficit After Stroke in Rats without affecting Infarction Volume(Cerebrovascular circulation / Stroke-1, The 71st Annual Scientific Meeting of the Japanese Circulation So
- PJ-654 Post-ischemic Administration of Fluvastatin Improves Cognitive Dysfunction in the Chronic Stage of Cerebral Infarction in Rat Model(Cerebrovascular circulation/Stroke-3 (H) PJ110,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meet
- PJ-652 Over-expression of HGF Improves Learning and Memory and Prevents Progressive Shrinkage of Thalamus in the Chronic Stage of Cerebral Infarction(Cerebrovascular circulation/Stroke-3 (H) PJ110,Poster Session (Japanese),The 70th Anniversary Annual Scie
- Transcription factor decoy oligonucleotide-based therapeutic strategy for renal disease
- PJ-740 Hepatocyte Growth Factor (HGF), but not Vascular Endothelial Growth Factor (VEGF), Attenuated Ang II-induced EC Senescence by Inhibiting PIP3/rac1 Activity(PJ124,Peripheral Cirulation/Vascular Disease (Therapy) 4 (H),Poster Session (Japanese),The 7
- OJ-060 Hepatocyte Growth Factor Attenuate Ang II-induced Inflammation and Proliferation of Smooth Muscle Cell through EGF Receptor Degradation(OJ10,Atherosclerosis, Basic (IHD),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Japanes
- PJ-686 Hepatocyte Growth Factor Can Attenuate Senescense of EPC through Anti-oxidative Stress Effect(Peripheral circulation/Vascular disease-6, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Application of Decoy Oligodeoxynucleotides for Arthritis
- 3 Functional Analysis of Novel Antimicrobial Peptide, AG (Angiogenic Peptide)-30, with Angiongenic Property, toward Clinical Application(The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Hepatocyte Growth Factor(HGF) as a Potential Index of Severity of Hypertension
- IS033 UP-REGULATION OF KEY TRANSCRIPTIONAL FACTOR FOR ANGIOGENESIS, ETS, AND INDUCTION OF ANGIOGENESIS BY IN VIVO GENE TRANSFER OF HUMAN HEPATOCYTE GROWTH FACTOR (HGF) INTO MYOCARDIUM
- IS028 GENE THERAPY OF RESTENOSIS BY IN VIVO GENE TRANSFER OF HUMAN HEPATOCYTE GROWTH FACTOR (HGF) THROUGH THE ACCELATION OF RE-ENDOTHELIALIZATION
- Contribution of a Vascular Modulator, Hepatocyte Growth factor (HGF), to the Pathogenesis of Cardiovascular Disease
- IS053 ANTI-APOPTOTIC ACTION OF HEPATOCYTE GROWTH FACTOR ON HUMAN AORTIC ENDOTHELIAL CELLS
- Potential Role of a Novel Vascular Modulator, Hepatocyte Growth Factor (HGF), in Cardiovascular Disease: Characterization and Regulation of Local HGF System
- PE-275 A Novel Strategy of the Gene Therapy for PAD Using Small RNA Interference of Cold Shock Domain Protein A(PE046,Atherosclerosis (Basic, Clinical/Diagnosis) (IHD),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation
- 2 Estrogen Decreases the Activation of RANK-RANKL System in Vascular Calcification(Young Investigator's Award for International Students Finalists Lecture (YIA International),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PJ-250 Cold shock domain protein A, novel regulator of angiogenesis in heart.(Coronary circulation, basic/clinical(03)(IHD),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- OE-185 Topical application of novel angiogenic peptide, AG-30, in wound healing model(Growth factor/Cytokine(01)(H),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- OE-040 FHL-2 Expresses in Endothelial Cell and Suppresses VEGF-induced Angiogenesis Via Sphingosine Kinase-1(Arrhythmia, diagnosis/Pathophysiology/EPS(01)(A),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society
- OJ-195 Pivotal Roles of Deubiquitinating Enzymes UCHL1, HAUSP, and CYLD in Vasculature as an Anti-proliferative and Anti-inflammatory Effect(Atherosclerosis, basic-3, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Adipose Tissue-Derived Stromal Cells as a Novel Option for Regenerative Cell Therapy
- PJ-752 A Novel Model of Vasculogenesis From ES Cells for Vascular Research and Regenerative Medicine(Development and differentiation-4 (M) PJ129,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- Gene therapy for ischemic brain disease with special reference to vascular dementia
- PJ-709 Amyloid β 1-40 Disrupts Vascular Regeneration through the Inhibition of Endothelial Akt signaling(Regeneration (angionenesis/myocardial regeneration)-7 (M) PJ119,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japane
- PJ-477 A Therapeutic Strategy to Treat Brain Ischemia : Over-expression of Hepatocyte Growth Factor Gene Reduced Ischemic Injury in Rat Model(Cerebrovascular Circulation/Stroke 1 (H) : PJ80)(Poster Session (Japanese))
- PJ-345 Hepatocyte Growth Factor Attenuates Angiotensin II Induced Renal Fibrosis through TGF-B Suppression by Anoikis of Myofibroblasts(Kidney/Renal circulation(06)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation
- OJ-125 HGF,but not VEGF, Attenuated Angiotensin II-induced Senescence in EPC through Anti-Oxidative Stress Effect by Inhibiting Rac1 Activation.(Regeneration(angiogenesis / myocardial regeneration)(02)(M),Oral Presentation (Japanese),The 72nd Annual Scien
- PJ-762 Requirement of HIF-1a Signaling on the Expression of Nkx2.5 for Normal Heart Developement in Xenopus(Development and differentiation-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-188 Angiogenic and Anti-fibrotic Actions of Hepatocyte Growth Factor Improve Cardiac Dysfunction in Porcine Ischemic Cardiomyopathy(Genetics/Genetically engineered models/Gene therapy-3 (M) PJ32,Poster Session (Japanese),The 70th Anniversary Annual Sci
- PJ-098 Ubiquitin C-terminal Hydroxylase L1 (UCHL1), the Causative Genes of Inherited Parkinson's Disease, Has an Anti-inflammatory Action in Endothelial Cells(Molecular biology, vascular-3 (H) PJ17,Poster Session (Japanese),The 70th Anniversary Annual Sci
- -441- HEMODYNAMIC, RENAL AND HORMONAL EFFECTS OF α-HUMAN ATRIAL NATRIURETIC PEPTIDE INJECTION IN PATIENTS WITH CONGESTIVE HEART FAILURE
- PE-114 Angiotensin II Blocker, Valsartan, Supresses the Development of Experimental Abdominal Aortic Aneurysm in Rats(Peripheral circulation/Vascular disease(03)(H),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Soc
- Aging of Blood Vessels
- Analysis and Comparison of New Candidate Loci for Hypertension between Genteic Hypertensive Rat Strains
- Leukemia Developing after^I Treatment for Thyroid Cancer in a Patient with Werner's Syndrome: Molecular and Cytogenetic Studies.
- PJ-691 Inhibition of Development of Experimental Aortic Abdominal Aneurysm in Rat Model by Atorvastatin through Inhibition of Macrophage Migration(Peripheral circulation/Vascular disease-6, The 71st Annual Scientific Meeting of the Japanese Circulation So
- PE-543 Inhibiton of Experimental Aortic Abdominal Aneurysm by Angiotensin Receptor Blocker, Valsartan(Peripheral circulation/Vascular disease-4, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Two Years Follow-up of Clinical Trial of Human Gene Therapy for Peripheral Arterial Disease Using Hepatocyte Growth Factor Gene Transfer(Peripheral Circulation/Vascular Disease (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Clinical Trial of Human Gene Therapy Using Hepatocyte Growth Factor Gene Transfer(Translational Research in Cardiovascular Disease, The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- FRS-013 Long Term Evaluation of Clinical Trial of Human Gene Therapy for Peripheral Arterial Disease Using Hepatocyte Growth Factor Gene Transfer(Angiogenesis and Regeneration Medicine in Cardiovascular Medicine (M) : FRS3)(Featured Research Session (Engl
- Increase in Peripheral Blood Flow by Intravenous Administration of Prostaglandin E1 in Patients with Peripheral Arterial Disease, Accompanied by Up-Regulation of Hepatocyte Growth Factor
- Inhibition of Restenosis by Beraprost Sodium (a Prostaglandin 12 Analogue) in the Porcine Coronary Artery after Angioplasty
- Results of Safety from Human Clinical Gene Therapy Using HGF (TREAT-HGF)
- Long Term Evaluation of Results from the First Stage in the Clinical Trial of Gene Therapy for Peripheral Arterial Disease
- Clinical Results of TREAT-HGF (Japan Trial to Treat Peripheral Arterial Disease by Therapeutic Angiogenesis Using Hepatocyte Growth Factor Gene Transfer)
- Evaluation of utility of prostagrandin E1 in the patients with ASO : Protective effect on endothelial function through up-regulation of HGF
- No increase in human HGF concentration in the patients transfected with human HGF plasmid : preliminary clinical results from TREAT-HGF
- Preliminary clinical results from TREAT-HGF (Japan Trial to Treat Peripheral Arterial Disease by Therapeutic Angiogenesis Using HGF Gene Transfer)
- Preliminary clinical results from TREAT-HGF : Gene therapy for PAD
- OJ-213 Prevention of Abdominal Aortic Aneurysm using Ribbon-type Chimeric Decoy Oligodeoxynucleotides against NF κ B and Ets in a Rat Model(Genetics/Genetically engineered models/Gene therapy-2(H/M), The 71st Annual Scientific Meeting of the Japanese Circ
- OJ-028 Role of NF κ B and Ets in Development of Abdominal Aortic Aneurysm in Human(Peripheral circulation/Vascular disease-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- 5 Clinical Trial of Human Gene Therapy for Peripheral Arterial Disease Using Hepatocyte Growth Factor Gene Transfer(Clinical Trials of Regeneration Therapy in Japan, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-391 Hypertension Accelerated Experimental Abdominal Aortic Aneurysm through Up-regulation of Transcription Factors, NFkB and Ets(Peripheral circulation-2 (H) OJ66,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japane
- OJ-338 Long Term Results and Sub-analysis from Clinical Trial of Human Gene Therapy for Peripheral Arterial Disease (PAD)(Genetics/Genetically engineered models/Gene therapy-1 (M) OJ57,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Me
- OJ-337 Regression of Abdominal Aortic Aneurysms by Chimeric Decoy Oligonucleotides against NF κ B and Ets Binding Sites in Rabbit Model(Genetics/Genetically engineered models/Gene therapy-1 (M) OJ57,Oral Presentation (Japanese),The 70th Anniversary Annual
- OJ-029 Suppression of Anastomotic Intimal Hyperplasia in Rabbit Hypercholesterolemic Model using Chimeric Decoy Oligodeoxynucleotides against NF κ B and E2F(Restenosis, basic/clinical-1 (IHD) OJ5,Oral Presentation (Japanese),The 70th Anniversary Annual Sc
- Improvement of Myocardial Dysfunction by Therapeutic Angiogenesis Induced by Transfection of HGF Gene in Porcine Chronic Myocardial Ischemia Model(Gene Therapy 2 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Regression of Experimental Rabbit Aortic Aneurysm by the Treatment with Chimeric Decoy Oligodeoxynucleotides (ODN) against Ets and NFkB(Gene Therapy 1 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Inhibitory Effect of NFκB Decoy Oligodeoxynucleotides (ODN) on the Neointimal Hyperplasia in Rabbit Vein Graft Model(Cardiovascular Surgery/CABG 2 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-090 Therapeutic angiogenesis by a transcription factor : Ets-1 for peripheral arterial disease(Gene Therapy 1 (IHD) : PJ15)(Poster Session (Japanese))
- FRS-041 One-beat Whole Heart Imaging Using the 2nd Spec 256-Multislice CT : First Clinical Data(New Cardiovascular Imagings-1 (I) FRS9,Featured Research Session,The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- 1. Hypertension and Genes
- Partial DiGeorge Syndrome at the Age of Thirty-Four.