Heterogeneity of Prognosis in Adult IgA Nephropathy, Especially with Mild Proteinuria or Mild Histological Features
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概要
- 論文の詳細を見る
Objective The present study was undertaken to clarify the clinical course and prognosis of adult patients with primary IgA nephropathy (IgAN), especially with mild proteinuria or mild histological alternations. Patients and Methods A population of 735 IgAN patients whom we were able to observe for more than two years was examined. Results A total of 115 patients (15.6%) was on dialysis during the observation period. The overall 5-year renal survival rate was 92.0%. On the other hand, 166 patients (22.6%) were in clinical remission. A group with mild proteinuria included 197 patients (26.8%). Forty-seven patients of this group showed minor glomerular abnormalities, whereas 12 patients with mild proteinuria showed severe mesangial involvement. Three patients with mild proteinuria were on dialysis during the observation period, whose proteinuria was increased during the clinical course. A group with minor glomerular abnormalities included 82 patients (11.2%). Forty-seven patients of this group showed mild proteinuria, of whom 12 patients showed moderate proteinuria. However, three patients with minor glomerular abnormalities who were not on dialysis showed loss of renal function. Conclusion These results indicated the heterogeneity of the course and prognosis in IgAN. Even if a patients initial clinical or histological findings are comparatively mild, strict follow-up management is needed.(Internal Medicine 40: 697-702, 2001)
- 社団法人 日本内科学会の論文
著者
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KOHNO Masakazu
Kagawa University
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Hirayama Aki
The Department Of Internal Medicine
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Yamagata Kunihiro
Pathophysiology Of Renal Diseases Graduate School Of Comprehensive Human Sciences University Of Tsuk
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KOYAMA Akio
Ibaraki Prefectural University of Health Science
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Yamagata Kunihiro
筑波大学医学専門学群附属病院 内科
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Kobayashi Masaki
The Department Of Nephrology Tokyo Medical University Kasumigaura Hospital
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USUI Joichi
the Department of Internal Medicine
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YAMAGATA Kunihiro
the Department of Internal Medicine
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KAI Hirayasu
the Department of Internal Medicine
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OUTEKI Takaaki
the Department of Internal Medicine
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YAMAMOTO Satoshi
the Department of Internal Medicine
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MURO Kaori
the Department of Internal Medicine
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YOH Keigyo
the Department of Internal Medicine
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TOMIDA Chie
the Department of Nephrology, Hitachi General Hospital
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HIRAYAMA Kouichi
the Department of Internal Medicine
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SUZUKI Satoshi
the Department of Internal Medicine, National Sakura Hospital
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NAGATA Michio
the Department of Pathology, Institute of Clinical Medicine, University of Tsukuba
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KOYAMA Akio
the Department of Internal Medicine
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Koyama A
筑波技術大学保健科学部附属東西医学統合医療センター
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Hirayama Kouichi
Pathophysiology Of Renal Diseases Graduate School Of Comprehensive Human Sciences University Of Tsuk
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Yoh Keigyou
Pathophysiology Of Renal Diseases Graduate School Of Comprehensive Human Sciences University Of Tsuk
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Koyama A
Univ. Tsukuba Tsukuba Jpn
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Tomida Chie
The Department Of Nephrology Hitachi General Hospital
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Morito Naoki
Pathophysiology Of Renal Diseases Graduate School Of Comprehensive Human Sciences University Of Tsuk
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Oteki Takaaki
Department Of Control For Pathological Processes Graduate School Of Comprehensive Human Sciences Uni
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Suzuki Satoshi
The Department Of Cardiovascular Medicine Kitakyushu Municipal Medical Center
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Nagata Michio
Department Of Nephrology Tokyo Medical University Ibaraki Medical Center
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Usui Joichi
Pathophysiology Of Renal Diseases Graduate School Of Comprehensive Human Sciences University Of Tsuk
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Usui Joichi
Laboratory Of Stem Cell Therapy Center For Experimental Medicine Institute Of Medical Science The Un
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Koyama A
Ibaraki Prefectural University For Health Sciences
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Konoshita Masahiko
First Department Of Internal Medicine Shiga University Of Medical Science
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Koyama Akio
Ibaraki Prefectural University Of Health Sciences
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Hirayama A
Department Of Internal Medicine Center For Integrative Medicine Tsukuba University Of Technology
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Yamamoto Satoshi
The Department of Cardiology, Saiseikai Izuo Hospital
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