Can High Frequency Ultrasound and MRI Diagnose Malignant Atheromatous Plaque In Vitro?.
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概要
- 論文の詳細を見る
It remains a vital clinical issue how to diagnose malignant atheromatous plaques consisting of ulcerative plaque and hemorrhagic plaque, which are potential risks for thrombosis and the arterial spasm. This study proposes further investigations to develop methods in order to detect this type of lesions by echocardiography. In this study, we tested high frequency (7.5MHz) US and 1.0 T MRI (T1 weighted SE, STIR; short time inversion recovery sequence, and T1 weighted fat suppression technique) for their precision in the diagnosis of atheromatous plaque as malignant or benign in post mortem human aorta.Ten hemorrhagic plaques were imaged as heterogeneous echo- pattern in the shoulder of plaques covered with high-echo capsule with US; however, these findings were also obtained from 2 of 16 non-hemorrhagic plaques. With T1SE, hemorrhagic plaques were revealed as mixed areas of reduced intensity and high intensity which were differentiated from fatty deposition with T1 weighted fat suppression technique. Ulcerative plaques were revealed as concave shaped plaques and diagnosed correctly with both methods. US was superior to MRI from the viewpoints of examination time and measuring wall thickness. US indicated intimal plus medial thickness of hemorrhagic plaque and non-hemorrhagic plaque at 4.3+1.1mm and 3.0+1.0mm (p<0.05) respectively. MRI was vulnerable to artifacts and its image was poorer in quality due to its lower resolution: however, probably because of its superior ability to distinguish fatty deposition from hemorrhage, MRI ultimately enabled more accurate diagnosis than US, as long as its image was fairly clear. The overall accuracies were 80% with US and 85.7% with MRI as confirmed by histological tests. From these results, the careful analysis of the two images obtained from US and MRI enables clinical diagnosis of malignant atheromatous plaques.
- International Heart Journal刊行会の論文
著者
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Yoshida Shigeo
Department Of Agricultural Chemistry Faculty Of Agriculture University Of Tokyo
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NIEMINEN Markku
Helsinki Central Hospital, Helsinki University
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PAANANEN Tapio
Helsinki Central Hospital, Helsinki University
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KAHRI Arvi
Helsinki Central Hospital, Helsinki University
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