THE ACE INHIBITOR ALACEPRIL SUPPRESSES ATHEROGENESIS INDEPENDENT OF SERUM LIPIDS IN CHOLESTEROL-FED RABBITS : Critical Analysis with New Ultrasound Technique

スポンサーリンク

概要

• 論文の詳細を見る

• The effects of alacepril, an angiotensin converting enzyme inhibitor, on atherogenesis were examined in rabbits fed a hypercholesterol diet. The process of atherogenesis was evaluated in vitro by high-resolution transesophageal ultra-sonography (TEE ∅4 mm, 7.5 MHz), by direct histological examination and by serum lipid examination. Of the 38 subjects, 18 were designated as the control hypercholesterol group (CH) and 20 received oral alacepril at 90 mg/day (ACE) for 13-22 weeks. Three rabbits in each group died due to pneumonia. TEE enabled a clear diagnosis as either normal, early stage or late stage of atherosclerosis. The intimal-medial thickness was significantly less in the ACE group than in the CH group, but only over the middle portion of the aorta. The ACE group had a smaller area of atheromatous plaque than the CH group (atheromatous index: 37±20* and 60±30% respectively, *p<0.02). Serum cholesterol and triglycerides were similar in the CH group (1590±653, 258±224) and the ACE group (1574±824, 303±360 respectively). In conclusion, alacepril reduced both the area of atheromatous atheroma plaque and wall hypertrophy independent of serum lipids in cholesterol-fed rabbits. In vitro miniature TEE is a dependable method for evaluating atherosclerosis in rabbits with hypercholesterolemia.

• 社団法人日本循環器学会の論文
• 1994-10-20

著者

• Fukuda Morimichi

  Department Of Ultrasound And Medical Diagnosis Sapporo Medical University

• Yoshida Shigeo

  Department Of Ultrasound And Medical Diagnosis Sapporo Medical University

• Yoshida Shigeo

  Department Of Agricultural Chemistry Faculty Of Agriculture University Of Tokyo

• FUKUDA Morimichi

  Department of Laboratory Diagnostic Ultrasound and Medical Electronics, School of Medicine, Sapporo Medical University

• ITOH KASUMI

  Department of Ultrasound and Medical Diagnosis, Sapporo Medical University

• ITOH Kasumi

  Department of Ultrasound & Medical Diagnosis, College of Medicine, Sapporo Medical University

関連論文

• 13C NMR Analyses on Conjugated Dienic Pheromones of Lepidoptera
• Stereoselective Synthesis of Some Isomers of Dodecadien-1-ol: Compounds Related to the Pine Moth Sex Pheromone
• (5Z, 7E)-5, 7-Dodecadien-1-ol: Female Sex Pheromone of the Pine Moth Dendrolimus spectabilis Butler
• Synthesis of Conjugated Enamino Compounds Inhibiting Photosynthetic Electron Transport(Pesticide Chemistry)
• An Analysis of BIGH3 Mutations in Patients with Corneal Dystrophies in the Kyushu District of Japan
• ENDOGENOUS AND EXOGENOUS CATECHOLAMINES CAN ACCENTUATE MYOCARDIAL ISCHEMIA ONLY WHEN CORONARY BLOOD FLOW IS BELOW A CRITICAL LEVEL
• -0978-STUDIES OF FUZZY ECHO IN LEFT ATRIUM WITH TRANS-ESOPHAGEAL ECHOCARDIOGRAPHY(II) : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• -167-SEMI-QUANTITATIVE EVALUATION OF ATHEROSCLEROTIC LESION OF THORACIC AORTA WITH HIGH RESOLUTION TRANSESOPHAGEAL ULTRASOUND : Arteriosclerosis : FREE COMMUNICATIONS(I) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIE
• Numerical simulations of mid-ocean ridge hydrothermal circulation including the phase separation of seawater
• Familial Cases with Age-Related Macular Degeneration
• Assessment of Tritium Behavior in Man Using a Modified Three-Compartment Model
• Pyrone derivatives : effective inhibitors of photosynthetic electron flow system
• Release and Uptake of Vitamin B12 by Asakusanori (Porphyra tenera) Seaweed
• Content and Characteristics of Vitamin B12 in Some Seaweeds
• Fluid Motion of the Outer Core in Response to a Temperature Heterogeneity at the Core-Mantle Boundary and Its Dynamo Action
• Structure/Activity Relationships of Grandinol: a Germination Inhibitor in Eucalyptus
• Germination Inhibitor from Eucalyptus pulverulenta
• THE ACE INHIBITOR ALACEPRIL SUPPRESSES ATHEROGENESIS INDEPENDENT OF SERUM LIPIDS IN CHOLESTEROL-FED RABBITS : Critical Analysis with New Ultrasound Technique
• Photosynthetic Electron Transport Inhibition By Pyrones and Pyridones: Structure-Activity Relationships
• Can High Frequency Ultrasound and MRI Diagnose Malignant Atheromatous Plaque In Vitro?.
• High Resolution Miniature Trans-Esophageal Echocardiography is Useful to Evaluate Atherosclerosis and the Effects of Alacepril in Hyper-Cholesterol Rabbits.

もっと見る 閉じる

スポンサーリンク