The Diversity of Left Ventricular Responses to Isoproterenol and Dibutyryl Cyclic AMP Infusion in Patients with Dilated Cardiomyopathy.
スポンサーリンク
概要
- 論文の詳細を見る
Sixteen patients with dilated cardiomyopathy were studied to define the abnormality of the β-adrenergic pathway non-invasively, using echocardiographic left ventricular responses to isoproterenol (ISP; 0.02μg/kg/min) and dibutyryl cyclic AMP (DBcAMP; 0.1mg/kg/min) infusion. The increase in fractional shortening induced by ISP (ΔFS-ISP) was 9±6% and that by DBcAMP (ΔFS-DBcAMP) was 7±3%. The patients could be divided into three groups according to their left ventricular response to each agent: Group A; normal response to ISP (ΔFS-ISP≥11%), Group B-1; poor response to ISP but better response to DBcAMP (ΔFS-ISP<11%, ΔFS-DBcAMP≥7%; damage to β-receptors), and Group B-2; poor response to ISP and DBcAMP (ΔFS-ISP <11%, ΔFS-DBcAMP<7%; damage including post receptor levels). Seven patients were in Group A, four in Group B-1, and five in Group B-2. DCM patients had a diversity of left ventricular responses to ISP and DBcAMP, according to the site of damage in the β-adrenergic pathway.
- International Heart Journal刊行会の論文
著者
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Iida Keiji
Department Of Cardiology Tsukuba Memorial Hospital
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Fujieda Katsuji
Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba
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Fujieda Katsuji
Department Of Internal Medicine Institute Of Clinical Medicine University Of Tsukuba
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Sugishita Yasuro
Department Of Intensive Care Anesthesiology Surgery And Internal Medicine Univ.of Tsukuba
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Yamaguchi Iwao
Department Of Cardiology
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Yukisada Kimihiko
Department Of Internal Medicine The University Of Tsukuba
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Yamaguchi Iwao
Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba
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KAWAO Satoru
Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba
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YUKISADA Kimihiko
Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba
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Yamaguchi Iwao
Department of Applied Chemistry, Faculty of Engineering, Osaka University
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