Effects of coronary collaterals on regional myocardial function during temporary coronary occlusion and hypoxic coronary perfusion.
スポンサーリンク
概要
- 論文の詳細を見る
The effects of coronary collaterals on regional myocardial function during temporary ischemia and hypoxia were studied in 12 open-chest dogs. Using an ultrasonic dimension gauge, systolic segment shortening in the left anterior descending coronary artery (LAD) area was measured at 1min after the following three experimental conditions: LAD occlusion and LAD hypoxic perfusion with nonoxygenated solutions at two different pressures (60mmHg and 120mmHg). Collateral function was assessed by both LAD diastolic retrograde pressure and the percentage of increase in left circumflex coronary flow at 1min after LAD occlusion. Systolic segment shortening decreased less with hypoxic perfusion than with occlusion, however, this beneficial effect on regional contraction was greater at a perfusion pressure of 60mmHg than at one of 120mmHg. The magnitude of decrease of systolic shortening was variable among individual dogs but correlated linearly with each of the two collateral function indexes, not only during occlusion but also during hypoxic perfusion.In conclusion, the preventive effect of hypoxic coronary perfusion on the early decline of regional myocardial function, in comparison to the changes seen during ischemia, may depend on coronary collaterals in addition to its washout effect on metabolites. In order to maintain myocardial function, perfusion pressure should be at an optimal level.
- International Heart Journal刊行会の論文
著者
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Saito Mamoru
Department Of Astronomy Faculty Of Science Kyoto University
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Kakihana Masaaki
Department Of Cardiology Tsukuba Memorial Hospital
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Ito Iwao
Department Of Internal Medicine Institute Of Clinical Medicine Institute Of Basic Medicine Tsukuba U
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Sugishita Yasuro
Department Of Intensive Care Anesthesiology Surgery And Internal Medicine Univ.of Tsukuba
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Ohtsuka Sadanori
Department Of Cardiology University Of Tsukuba Graduate School Of Comprehensive Human Sciences
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Ohtsuka Sadanori
Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba
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KAKIHANA Masaaki
Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba
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SAITO Mamoru
Department of Physiology, Institute of Basic Medical Sciences, University of Tsukuba
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